This gene encodes a protein which belongs to the C2H2-type zinc finger proteins subclass of the Gli family. They are characterized as DNA-binding transcription factors and are mediators of Sonic hedgehog (Shh) signaling. The protein encoded by this gene localizes in the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. Mutations in this gene have been associated with several diseases, including Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, and postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008].
Hehemann, Kalmanek, Choe, Dynda, Hu, Quek, Harrington, Stupp, McVary, Podlasek: "Sonic hedgehog regulation of human rhabdosphincter muscle:Potential implications for treatment of stress urinary incontinence." in: Neurourology and urodynamics, Vol. 37, Issue 8, pp. 2551-2559, (2019) (PubMed).
Jackson, Smith, Amarsaikhan, Han, Neil, Boi, Vrabel, Tolosa, Almada, Fernandez-Zapico, Elsawa: "Modulation of the IL-6 Receptor α Underlies GLI2-Mediated Regulation of Ig Secretion in Waldenström Macroglobulinemia Cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 195, Issue 6, pp. 2908-16, (2015) (PubMed).
Kumari, Chaurasia, Kumar, Dash: "Anti-apoptotic role of sonic hedgehog on blood platelets." in: Thrombosis research, Vol. 134, Issue 6, pp. 1311-5, (2014) (PubMed).
Kanda, Mitsuyasu, Nakao, Kawano, Goto, Matsubara, Nakamura: "Anti-apoptotic role of the sonic hedgehog signaling pathway in the proliferation of ameloblastoma." in: International journal of oncology, Vol. 43, Issue 3, pp. 695-702, (2013) (PubMed).
Haycraft, Banizs, Aydin-Son, Zhang, Michaud, Yoder: "Gli2 and Gli3 localize to cilia and require the intraflagellar transport protein polaris for processing and function." in: PLoS genetics, Vol. 1, Issue 4, pp. e53, (2005) (PubMed).
Aliases for GLI3 抗体
GLI family zinc finger 3 (GLI3) 抗体 GLI family zinc finger 3 (Gli3) 抗体 GLI family zinc finger 3 L homeolog (gli3.L) 抗体 GLI-Kruppel family member GLI3 (Gli3) 抗体 GLI family zinc finger 3 (gli3) 抗体 ACLS 抗体 add 抗体 AI854843 抗体 AU023367 抗体 Bph 抗体 GCPS 抗体 GLI3 抗体 GLI3-190 抗体 GLI3FL 抗体 im:7142603 抗体 PAP-A 抗体 PAPA 抗体 PAPA1 抗体 PAPB 抗体 Pdn 抗体 PHS 抗体 PPDIV 抗体 xgli3 抗体 Xt 抗体