Recombinant GLI3 抗体 (AA 1300-1600)
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Quick Overview for Recombinant GLI3 抗体 (AA 1300-1600) (ABIN6943536)
抗原
See all GLI3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1300-1600
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原理
- GLI3 Recombinant Antibody
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant protein within human Gli3 aa 1300-1600.
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亚型
- IgG
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应用备注
- WB(1:300-5000), IF(ICC)(1:50-200)
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS ( pH 7.4), 1 % BSA, 0.02 % Proclin 300, and 50 % Glycerol
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- GLI3 (GLI Family Zinc Finger 3 (GLI3))
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别名
- GLI3
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背景
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Synonyms: Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3 full-length protein, Transcriptional repressor GLI3R, GLI3 C-terminally truncated form, GLI3 form of 83 kDa, GLI3-190, GLI3FL, GLI3-83,
Background: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
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基因ID
- 2737
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UniProt
- P10071
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途径
- Hedgehog Signaling
抗原
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