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14 of 15 (93%) anastomosing haemangiomas in the case series showed recurrent mutations in GNAQ or GNA14.
The findings of the work indicate a role for Galphaq and/or Galpha14 and in CCR2a/CCR2b-stimulated Rho A GTPase-mediated serum response factor activation.
findings identify GNA14 mutations as a cause of childhood vascular tumors, offer insight into mechanisms of oncogenic transformation by mutations affecting Gaq family members, and identify potential targets for therapeutic intervention
Study suggests that the previously identified PLCbeta-interacting residues are insufficient to ensure productive interaction of Galpha14 with PLCbeta, while an intact N-terminal half of Galpha14 is apparently required for PLCbeta interaction.
TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells.
TPR1 is required for Galpha14 to stimulate Ras-dependent signaling pathways, but not for the propagation of signals along Ras-independent pathways.
activation of the IKK/NFkappaB signaling cascade by SSTR2 requires a complicated network consisting of Galpha(14), protein kinase C, CamkII, ERK, and c-Src
G14alpha and G16alpha are palmitoylated at distinct polycysteine sequences, and that the adjacent polybasic domain is not required for Galpha palmitoylation but is important for localization and functional activity of heterotrimeric G proteins
The ability of CCR1 to signal through Galpha(14/16) thus provides a linkage for chemokines to regulate NF-kappaB-dependent responses.
The phylogenetic trees reveal that porcine Gna14, is evolutionarily close to the human homolog.
These results suggest the important roles of G alpha14 in sweet/umami taste signal transduction in the posterior region of the tongue.
This gene encodes a member of the guanine nucleotide-binding, or G protein family. G proteins are heterotrimers consisting of alpha, beta and gamma subunits. The encoded protein is a member of the alpha family of G proteins, more specifically the alpha q subfamily of G proteins. The encoded protein may play a role in pertussis-toxin resistant activation of phospholipase C-beta and its downstream effectors.
, guanine nucleotide binding protein (G protein), alpha 14
, guanine nucleotide binding protein (G protein), alpha 14 b
, guanine nucleotide-binding protein subunit alpha-14-like
, G-protein subunit alpha-14
, g alpha-14
, guanine nucleotide-binding protein 14
, guanine nucleotide-binding protein subunit alpha-14
, G-protein subunit GL1 alpha
, G protein alpha subunit 14
, guanine nucleotide binding protein (G protein), alpha 14 a
, TGFB inducible early growth response 3