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a novel germline gain-of-function Galpha11 mutation, Val340Met, causing Autosomal Dominant Hypocalcemia Type 2 demonstrates the importance of the Galpha11 C-terminal region for G-protein function and CaSR (显示 CASR ELISA试剂盒) signal transduction.
studies have identified a third Galpha11 mutation (Thr54Met) causing Familial Hypocalciuric Hypercalcemia Type 2 and reveal a critical role for the Galpha11 interdomain interface in CaSR (显示 CASR ELISA试剂盒) signaling and Ca(2 (显示 CA2 ELISA试剂盒)+) o homeostasis.
Adenocarcinomas or adenomas derived from pigmented ciliary epithelium is distinguished from uveal melanoma by the absence of SOX10 (显示 SOX10 ELISA试剂盒) expression and presence of the BRAF (显示 BRAF ELISA试剂盒) V600E mutation.
Mutations in GNAQ (显示 GNAQ ELISA试剂盒) and GNA11 genes in Greek uveal melanoma population present frequencies that qualify them as potential targets for customized therapy.
Sporadic melanotic schwannoma with overlapping features of melanocytoma bearing a GNA11 mutation in an adolescent girl.
we find iris melanomas to be related genetically to choroidal and ciliary body melanomas, frequently harboring GNAQ (显示 GNAQ ELISA试剂盒), GNA11, and EIF1AX (显示 EIF1AX ELISA试剂盒) mutations.
GNAQ and GNA11 mutations occur frequently in mucosal melanoma and may be a prognostic factor for MM. Our data implicate that GNAQ/11 may be potential targets for targeted therapy of mucosal melanoma.
CGRP (显示 S100A12 ELISA试剂盒) family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas (显示 GNAS ELISA试剂盒), Galphai, and Galphaq (显示 GNAQ ELISA试剂盒)/11 pathways.
The identified GNA11 mutation results in biochemical abnormalities typical for autosomal dominant hypocalcemia. Additional features, including short stature and early intracranial calcifications, cosegregated with the mutation.
In 33 CASR (显示 CASR ELISA试剂盒)-negative patients with suspected FHH (显示 CASR ELISA试剂盒), Data found two (~6%) with a mutation in AP2S1 (显示 AP2S1 ELISA试剂盒) (p.Arg15Leu and p.Arg15His). Family screening confirmed the genotype-phenotype correlations. Data did not identify any pathogenic mutations in GNA11.
G protein-coupled receptor Kinase 2 reacts with this protein's signaling homology domain for binding G protein subunits
The phylogenetic trees reveal that porcine Gna11, is evolutionarily close to the human homolog.
Galpha11 is inhibitory to osteoanabolic actions of both parathyroid hormone (显示 PTH ELISA试剂盒) and exercise
results suggest that alveolar Gq/11 signaling maintains alveolar homeostasis and likely independently increases TGFbeta (显示 TGFB1 ELISA试剂盒) activation in response to the mechanical stress of the epithelium and decreases epithelial IL-33 (显示 IL33 ELISA试剂盒) synthesis. Together, these findings suggest that disruption of Gq/11 signaling promotes inflammatory emphysema but protects against mechanically induced lung injury.
the results have identified 138 and 150 ovarian genes that are up-regulated or down-regulated, respectively, at the end of gestation in a Galphaq (显示 GNAQ ELISA试剂盒)/11-dependent fashion.
claudin-3 (显示 CLDN3 ELISA试剂盒) and claudin-5 (显示 CLDN5 ELISA试剂盒) expression is increased by DHEAS (显示 SULT2A1 ELISA试剂盒) and tight junction formation is stimulated via a Gnalpha11-coupled receptor in Sertoli cells
ZIP9/Gna11 interactions mediate the non-classical testosterone signaling cascade in spermatogenic GC-2 cells.
the conditional deletion of Galphaq (显示 GNAQ ELISA试剂盒)/11 from granulosa/luteal cells prevents the progesterone withdrawal that occurs at the end of pregnancy and impairs parturition.
Loss of gq/11 genes does not abolish melanopsin (显示 OPN4 ELISA试剂盒) phototransduction.
Mediated by lysophosphatidylinositol, Galpha(q (显示 GNAQ ELISA试剂盒)/11) is activated in sensory neurons.
Dehydroepiandrosterone sulfate (DHEAS (显示 SULT2A1 ELISA试剂盒))-induced signaling is mediated through interaction with a membrane-bound G-protein-coupled receptor (显示 GPR34 ELISA试剂盒), since silencing of Gnalpha11 leads to the abolition of the DHEAS (显示 SULT2A1 ELISA试剂盒)-induced stimulation of Erk1/2 (显示 MAPK1/3 ELISA试剂盒), ATF-1 (显示 AFT1 ELISA试剂盒), and CREB (显示 CREB1 ELISA试剂盒).
Pasteurella multocida toxin prevents osteoblast differentiation by transactivation of the MAP-kinase (显示 MAPK1 ELISA试剂盒) cascade via the Galpha(q (显示 GNAQ ELISA试剂盒)/11)--p63RhoGEF--RhoA (显示 RHOA ELISA试剂盒) axis.
may be involved in mediating second messenger signals from the endothelin receptor in adipocytes
Guanine nucleotide-binding protein alpha-11 subunit
, phospholipase C-activating G-protein
, G-protein subunit alpha-11
, g alpha-11
, guanine nucleotide-binding protein G(y) subunit alpha
, guanine nucleotide-binding protein subunit alpha-11
, guanine nucleotide-binding protein, Gq class, GNA11
, G-protein subunit GL2 alpha
, G alpha-11
, guanine nucleotide binding protein alpha 11
, guanine nucleotide regulatory protein G alpha 11
, guanine nucleotide-binding protein alpha 11 subunit