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Vav3 is a novel TRAF6 (显示 TRAF6 ELISA试剂盒) interaction partner that functions in the activation of cooperative signaling between T6BSs and the IVVY motif in the RANK signaling complex.
this study shows that the anti-tumor effects of astragaloside IV are mediated by the downregulation of Vav3-mediated Rac1/MAPK (显示 MAPK1 ELISA试剂盒) activation
Our results indicated that individuals carrying the VAV3 rs7528153 TT genotype were at a significantly increased risk of developing Paget's Disease of Bone
Vav3 was accumulated in cell protrusions, contributed to the formation of membrane protrusions, and thereby increased the motility and invasiveness of pancreatic ductal adenocarcinoma cells
Vav3 inhibition can suppress cell activity and promote apoptosis by regulating the apoptosis-related genes through the ERK (显示 EPHB2 ELISA试剂盒) pathway
Data show that microRNA miR (显示 MLXIP ELISA试剂盒)-499-5p targeted 3' untranslated regions (3'-UTR (显示 UTS2R ELISA试剂盒)) of vav 3 oncogene protein (VAV3).
Results found that OSR2, VAV3, and PPFIA3 (显示 PPFIA3 ELISA试剂盒) were significantly hypermethylated in gastric cancer (GC) patients offering a good alternative in a simple, promising, and noninvasive detection of GC.
Data show although no any significant differences between patient groups and lean subjects of proteins SYT4 (显示 SYT4 ELISA试剂盒), BAG3 (显示 BAG3 ELISA试剂盒), APOA1 (显示 APOA1 ELISA试剂盒), and VAV3, except for VGF (显示 VGF ELISA试剂盒) protein, there was a trend between the expression of these four genes and their protein levels.
VAV3 overexpression is a novel biomarker for poor prognosis and survival in ovarian carcinoma.
VAV3 overexpression could be a useful marker for predicting the outcomes of CRC (显示 CALR ELISA试剂盒) patients and that VAV3 targeting represents a potential modality for treating CRC (显示 CALR ELISA试剂盒)
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Vav3 is a regulator of retinal progenitor cell differentiation, thus highlighting a novel role for guanine nucleotide exchange factors in retinogenesis.
Platelet P-Rex and Vav (显示 VAV1 ELISA试剂盒) family Rac (显示 AKT1 ELISA试剂盒)-GEFs play important proinflammatory roles in leukocyte recruitment.
chow diet-fed Vav3 knockout mice develop an incomplete postreceptor insulin (显示 INS ELISA试剂盒) state characterized by typical liver and plasma metabolic syndrome-like pathophysiologies that is not associated to other defects such as white adipocyte hypertrophy and obesity
Data demonstrate that the co-expression of the exchange factors Vav2 (显示 VAV2 ELISA试剂盒) and Vav3 is critical for the development of this tumor type.
Vav2 (显示 VAV2 ELISA试剂盒) and Vav3 are required for normal peripheral nerve degeneration/regeneration, revascularization and functional recovery.
Vav3 collaborates with p190 (显示 CNTNAP1 ELISA试剂盒)-BCR-ABL (显示 ABL1 ELISA试剂盒) in lymphoid progenitor leukemogenesis, proliferation, and survival.
Dectin-1 (显示 CLEC7A ELISA试剂盒) activates the integrin Mac-1 (显示 ITGAM ELISA试剂盒) in neutrophils via Vav1 (显示 VAV1 ELISA试剂盒) and Vav3 signaling to promote Candida albicans clearance.
study discloses an essential and nonredundant role for this Vav (显示 VAV1 ELISA试剂盒) family member in axon guidance events in brainstem neurons that control blood pressure and respiratory rates
CD36 (显示 CD36 ELISA试剂盒) contributes to activation of Vav-1 (显示 VAV1 ELISA试剂盒), -2, and -3 in aortae from hyperlipidemic mice
This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases that activate pathways leading to actin cytoskeletal rearrangements and transcriptional alterations. This gene product acts as a GEF preferentially for RhoG, RhoA, and to a lesser extent, RAC1, and it associates maximally with the nucleotide-free states of these GTPases. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.
vav 3 oncogene
, guanine nucleotide exchange factor VAV3
, vav 3 protein