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Using immunohistochemistry, we validated that MS4A2 (显示 MS4A1 蛋白), the beta subunit (显示 POLG 蛋白) of the IgE receptor expressed on mast cells, is a favorable prognostic indicator and show that MS4A2 (显示 MS4A1 蛋白) gene expression is an independent prognostic marker for early-stage lung cancer patient survival.
in patients with allergic rhinitis without asthma, the FCER1B rs569108 and rs512555 polymorphisms are associated with increased risk of developing allergic rhinitis and with lower IgE levels.
study found a difference in the frequencies of genotypes of FcvarepsilonRIbeta subunit int 2 (显示 FGF3 蛋白) in allergic rhinitis patients and controls. The FcvarepsilonRIbeta subunit int 2 (显示 FGF3 蛋白) gene polymorphism was found to be associated with allergic rhinitis in the Polish cohort
MS4A2 (显示 MS4A1 蛋白) was differentially expressed between Fibromyalgia patients and healthy controls.
FcepsilonRIbeta -109C/T and IFN-gamma (显示 IFNG 蛋白) 874T/A polymorphisms may be influencing factors for asthma in the Asian population
The results explain how initial membrane interactions of clustered IgE-Fcepsilon RI complexes lead to downstream cellular responses.
Data indicated that the MS4A2 (显示 MS4A1 蛋白) gene E237G variant may be a risk factor for developing atopic asthma and the promoter -109T allele is a potential risk factor of asthma in Asians.
Cytoplasmic FcepsilonRIbeta, which is not co-localized with FcepsilonRIalpha, may function as a negative regulator, as it can capture important signalling molecules such as Lyn (显示 LYN 蛋白).
t-FcepsilonRIbeta mediates Ca2 (显示 CA2 蛋白)+ -dependent microtubule formation, which promotes degranulation and cytokine release.
The interaction between Lyn (显示 LYN 蛋白) and FcepsilonRIbeta is indispensable for FcepsilonRI (显示 FCER1G 蛋白)-mediated human mast cell activation.
Analysis of the conformation and thermal stability of the high-affinity IgE Fc receptor beta chain polymorphic proteins has been presented.
chemotaxis toward antigen is controlled in mast cells by a cross-talk among FcepsilonRI (显示 FCER1A 蛋白), tetraspanin CD9 (显示 CD9 蛋白), transmembrane adaptor proteins NTAL (显示 LAT2 蛋白) and LAT (显示 LAT 蛋白), and cytoskeleton-regulatory proteins of the ERM (显示 ETV5 蛋白) family
Findings indicate that SLP-76 (显示 LCP2 蛋白) is an essential signaling component for basophil activation downstream of both FcepsilonRI (显示 FCER1A 蛋白) and the IL-3 (显示 IL-3 蛋白) receptor.
FcRbeta is a critical element in mast cell synergistic degranulation response through FcepsilonRI (显示 FCER1A 蛋白) & adenosine receptors. PI3K-signaling through FcRbeta-ITAM is a crucial participant in augmentation of FcepsilonRI (显示 FCER1A 蛋白)-mediated degranulation by adenosine.
inhibition of FcepsilonRI (显示 FCER1A 蛋白)-dependent mast cell activation can suppress allergic contact dermatitis
Gene expression profiling after stimulation via high-affinity Fcepsilon receptor I (FcepsilonRI (显示 FCER1A 蛋白)), showed the transcriptional levels of several CC chemokines were markedly increased.
FcepsilonRIbeta functions to both selectively amplify (degranulation and leukotriene secretion) and dampen (lymphokine (显示 IL2 蛋白)) mast cell effector responses
IgE receptors are expressed on sensory neurons in mice. Immunostaining revealed that the high affinity IgE receptor FcepsilonRI (显示 FCER1A 蛋白) was expressed in cultured dorsal root ganglion cells.
FcepsilonRI (显示 FCER1A 蛋白) beta-chain regulates calcium uptake in mast cells via the immunoreceptor tyrosine-based activation motif.
IgE signaling suppresses FcepsilonRIbeta expression.
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of membrane-spanning 4A gene family members. Alternative splicing results in multiple transcript variants encoding distinct proteins. Additional transcript variants have been described but require experimental validation.
Fc fragment of IgE, high affinity I, receptor for; beta polypeptide
, High affinity immunoglobulin epsilon receptor beta-subunit (FcERI) (IgE Fc receptor, beta-subunit) (Fc epsilon receptor I beta-chain)
, high affinity IgE receptor beta subunit
, high affinity immunoglobulin epsilon receptor subunit beta
, igE Fc receptor subunit beta
, immunoglobulin E receptor, high affinity, beta polypeptide
, Fc receptor, IgE, high affinity I, beta polypeptide
, fc epsilon receptor I beta-chain
, membrane-spanning 4-domains, subfamily A, member 1
, IgE Fc receptor subunit beta
, Membrane-spanning 4-domains subfamily A member 1
, Membrane-spanning 4-domains, subfamily A, member 1
, beta polypeptide)
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for
, membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)