This gene encodes a non-catalytic component of the human exosome, a complex with 3'-5' exoribonuclease activity that plays a role in numerous RNA processing and degradation activities. Related pseudogenes of this gene are found on chromosome 19 and 21. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2012].
Nojima, Tellier, Foxwell, Ribeiro de Almeida, Tan-Wong, Dhir, Dujardin, Dhir, Murphy, Proudfoot: "Deregulated Expression of Mammalian lncRNA through Loss of SPT6 Induces R-Loop Formation, Replication Stress, and Cellular Senescence." in: Molecular cell, Vol. 72, Issue 6, pp. 970-984.e7, (2019) (PubMed).
Hsin, Li, Hoque, Tian, Manley: "RNAP II CTD tyrosine 1 performs diverse functions in vertebrate cells." in: eLife, Vol. 3, pp. e02112, (2014) (PubMed).
Fan, Huang-Liu, Shen, Ju, Lin, Pai, Huang, Ho, Tsai, Tsai, Huang: "Reduction of TLR4 mRNA stability and protein expressions through inhibiting cytoplasmic translocation of HuR transcription factor by E₂ and/or ERα in LPS-treated H9c2 cardiomyoblast cells." in: The Chinese journal of physiology, Vol. 57, Issue 1, pp. 8-18, (2014) (PubMed).