ERG 产品
(ERG, ETS transcription factor (ERG))
Categories
This gene encodes a member of the erythroblast transformation-specific (ETS) family of transcriptions factors. All members of this family are key regulators of embryonic development, cell proliferation, differentiation, angiogenesis, inflammation, and apoptosis. The protein encoded by this gene is mainly expressed in the nucleus. It contains an ETS DNA-binding domain and a PNT (pointed) domain which is implicated in the self-association of chimeric oncoproteins. This protein is required for platelet adhesion to the subendothelium, inducing vascular cell remodeling. It also regulates hematopoesis, and the differentiation and maturation of megakaryocytic cells. This gene is involved in chromosomal translocations, resulting in different fusion gene products, such as TMPSSR2-ERG and NDRG1-ERG in prostate cancer, EWS-ERG in Ewing's sarcoma and FUS-ERG in acute myeloid leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jan 2012].
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Featured ERG Categories
Recommended ERG 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IF, IHC (p)
Validations
- (5)
Cat. No.
ABIN1498076
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (4)
Cat. No.
ABIN6261595
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, FACS
Validations
- (4)
Cat. No.
ABIN185550
Quantity
100 μg
Datasheet
Datasheet
Recommended ERG 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (2)
Cat. No.
ABIN2720464
Quantity
20 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122812
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1353056
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our ERG Products
: "Analytical platform evaluation for quantification of ERG in prostate cancer using protein and mRNA detection methods." in: Journal of translational medicine, Vol. 13, pp. 54, (2015) (PubMed).: "FZD4 as a mediator of ERG oncogene-induced WNT signaling and epithelial-to-mesenchymal transition in human prostate cancer cells." in: Cancer research, Vol. 70, Issue 17, pp. 6735-45, (2010) (PubMed).
: "Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer." in: Science (New York, N.Y.), Vol. 310, Issue 5748, pp. 644-8, (2005) (PubMed).
Synonyms and alternative names related to ERG
ERG, ETS transcription factor (ERG), ERG, ETS transcription factor (Erg), v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog (erg.L), v-ets avian erythroblastosis virus E26 oncogene homolog (erg), v-ets avian erythroblastosis virus E26 oncogene homolog S homeolog (erg.S), ETS transcription factor (Erg), potassium voltage-gated channel subfamily H member 6 (KCNH6), D030036I24Rik, erg, ERG, erg-3, erg_A, erg_E, KCNH2, p55, zgc:103429Protein level used designations for ERG
- TMPRSS2/ERG fusion
- ets-related
- transcriptional regulator ERG
- transcriptional regulator ERG (transforming protein ERG)
- v-ets avian erythroblastosis virus E26 oncogene related
- v-ets erythroblastosis virus E26 oncogene homolog
- v-ets erythroblastosis virus E26 oncogene like
- avian erythroblastosis virus E-26 (v-ets) oncogene related
- vascular ETS factor
- erg1
- erg gene (erg_E)
- v-ets erythroblastosis virus E26 oncogene homolog (avian)
- transcriptional regulator Erg
- ERG-1
- HERG protein
- eag-related protein 1
- ether-a-go-go-related gene potassium channel 1
- ether-a-go-go-related protein 1
- potassium voltage-gated channel subfamily H member 2
- voltage-gated potassium channel subunit Kv11.1
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