DUSP6 产品
(Dual Specificity Phosphatase 6 (DUSP6))
Categories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured DUSP6 Categories
DUSP6 抗体
High quality antibodies with extensive validation data.
DUSP6 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
DUSP6 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended DUSP6 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), RNAi
Validations
- (3)
- (6)
Cat. No.
ABIN560670
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (5)
Cat. No.
ABIN7436195
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IF, IHC (p)
Validations
- (6)
Cat. No.
ABIN392864
Quantity
400 μL
Datasheet
Datasheet
Recommended DUSP6 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6955468
Quantity
96 tests
Datasheet
Datasheet
Recommended DUSP6 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122714
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1352140
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3079239
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our DUSP6 Products
: "Hepatitis C virus-induced reduction in miR-181a impairs CD4(+) T-cell responses through overexpression of DUSP6." in: Hepatology (Baltimore, Md.), (2015) (PubMed).: "TSH signaling overcomes B-RafV600E-induced senescence in papillary thyroid carcinogenesis through regulation of DUSP6." in: Neoplasia (New York, N.Y.), Vol. 16, Issue 12, pp. 1107-20, (2014) (PubMed).
: "Co-inhibition of NF-κB and JNK is synergistic in TNF-expressing human AML." in: The Journal of experimental medicine, Vol. 211, Issue 6, pp. 1093-108, (2014) (PubMed).
: "Dual specificity phosphatase 6 as a predictor of invasiveness in papillary thyroid cancer." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 167, Issue 1, pp. 93-101, (2012) (PubMed).
: "Signal integration and coincidence detection in the mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) cascade: concomitant activation of receptor tyrosine kinases and of ..." in: The Journal of biological chemistry, Vol. 286, Issue 29, pp. 25663-74, (2011) (PubMed).
: "Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis." in: The American journal of pathology, Vol. 175, Issue 2, pp. 867-81, (2009) (PubMed).
: "Mitogen-activated protein kinase activation and regulation in the pressure-loaded fetal ovine heart." in: American journal of physiology. Heart and circulatory physiology, Vol. 290, Issue 4, pp. H1587-95, (2006) (PubMed).
: "Abrogation of DUSP6 by hypermethylation in human pancreatic cancer." in: Journal of human genetics, Vol. 50, Issue 4, pp. 159-67, (2005) (PubMed).
: "Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 8, pp. 1034-42, (2005) (PubMed).
: "Both nuclear-cytoplasmic shuttling of the dual specificity phosphatase MKP-3 and its ability to anchor MAP kinase in the cytoplasm are mediated by a conserved nuclear export signal." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41882-91, (2004) (PubMed).
Synonyms and alternative names related to DUSP6
dual specificity phosphatase 6 (DUSP6), dual specificity phosphatase 6 (Dusp6), dual specificity phosphatase 6 (dusp6), dual specificity phosphatase 6 L homeolog (dusp6.L), Dual specificity protein phosphatase 6 (dus6), 1300019I03Rik, DUSP6, dusp6, HH19, MKP-3, MKP3, Mkp3, mkp3, PYST1, pyst1, wu:fd99d09Protein level used designations for DUSP6
- MAP kinase phosphatase 3
- dual specificity protein phosphatase 6
- dual specificity protein phosphatase PYST1
- mitogen-activated protein kinase phosphatase 3
- serine/threonine specific protein phosphatase
- MKP-3
- etID14116.25
- MAP kinase phosphatase X17C
- dual specificity phosphatase 6
- Dual specificity protein phosphatase 6
- dual specificity protein phosphatase 6-like
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