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Human SOX2 Protein expressed in HEK-293 Cells - ABIN2732450
Soufi, Garcia, Jaroszewicz, Osman, Pellegrini, Zaret: Pioneer transcription factors target partial DNA motifs on nucleosomes to initiate reprogramming. in Cell 2015
Six SOX2 positive synovial sarcoma cases were analyzed by FISH using a SOX2/CEN3 (显示 CETN3 蛋白) dual color FISH probe
Tumor tissue Sox2 expression was not positively correlated with histologic grade, pathological tumor size and prognosis in surgical patients with triple-negative breast cancer.
Study in glioma stem-like cells (GSCs) identified SOX2 as one of downstream METTL3 (显示 METTL3 蛋白) targets and further recruitment of HuR (显示 ELAVL1 蛋白) onto m6A (显示 GPM6A 蛋白)-modified sites in SOX2 is essential for SOX2 mRNA stabilization. METTL3 (显示 METTL3 蛋白) alters the DNA repair efficiency and radiation sensitivity partially via SOX2 in GSCs.
Myeloid Zinc Finger 1 (显示 ZFP42 蛋白) and GA Binding Protein Co-Operate with Sox2 in Regulating the Expression of Yes-Associated Protein 1 (显示 YAP1 蛋白) in Cancer Cells
Human cytomegalovirus IE1 causes SOX2 downregulation by promoting the nuclear accumulation and inhibiting the phosphorylation of STAT3 (显示 STAT3 蛋白), a transcriptional activator of SOX2 expression.
hypopharyngeal squamous cell carcinomas characteristically almost completely lacking SOX2 expression appeared to be aggressive neoplasms with high recurrence rates. Promoter hypermethylation was determined to be a major mechanism underlying epigenetic SOX2 silencing
this study shows that basaloid squamous cell carcinoma and basal cell carcinoma of the head and neck can be readily distinguished by a limited panel consisting primarily of EMA, and supported by SOX2 and p16
Results show that the levels of small nucleolar RNA host gene 5 (SNHG5) and SRY (sex determining region Y)-box 2 protein (SOX2) were significantly downregulated in osteoarthritis (OA) tissues, while the level of miR (显示 MLXIP 蛋白)-26a was upregulated.
SOX2 copy number increases are detectable in a substantial proportion of high-grade HPV-positive vulvar carcinomas with basaloid differentiation.
The staining patterns did not reliably distinguish cervical intraepithelial neoplasia, grade 3 (CIN (显示 PDXP 蛋白) 3) from CIN (显示 PDXP 蛋白) 3-like Squamous cell carcinoma (SCC (显示 CYP11A1 蛋白)). Small infiltrative tumor nests around the margins of CIN (显示 PDXP 蛋白) 3 or deeply invasive CIN (显示 PDXP 蛋白) 3-like SCC (显示 CYP11A1 蛋白) often showed a localized reduction in SOX2 expression suggesting SOX2 downregulation during the transition to invasive growth.
SOX2 localizes exclusively in the inner cell mass of bovine blastocysts, and its downregulation negatively impacts preimplantation development (显示 MTA2 蛋白).
analysis of pluripotency gene expression of OCT4, SOX2 and NANOG and mRNA levels of some of their downstream targets in bovine oocytes and early embryos
Sox2 displayed relatively the same methylation levels between sperm and oocytes
Here we describe an optimized DamID method coupled with next-generation sequencing (DamID-seq) in mouse cells and demonstrate the identification of the binding sites of two TFs, POU5F1 (显示 POU5F1 蛋白) (also known as OCT4 (显示 POU5F1 蛋白)) and SOX2, in as few as 1000 embryonic stem cells (ESCs (显示 NR2E3 蛋白)) and neural stem cells (NSCs), respectively.
Results show that Sox2 is necessary for the time course of astrocytic maturation in early postnatal retinal development, as well as for the establishment and/or maintenance of astrocytic morphology in adulthood, evidenced by the regional loss of GFAP (显示 GFAP 蛋白) expression and aberrant sprouting into the inner retina after its removal.
SOX2 functions downstream of HH signaling to regulate lingual epithelium homeostasis.
SOX2 regulates proliferation through conserved mechanisms and target genes in both germ layers examined. Together, these findings demonstrate how SOX2 simultaneously regulates cell-type-specific, as well as core transcriptional programs in neural and endodermal stem cells.
Nup153 (显示 NUP153 蛋白) and Sox2 bind and co-regulate hundreds of genes.
late neuronal development depends directly on Sox2 for differentiation and on the survival of hair cells, possibly derived from common neurosensory precursors.
These observations support a role for YY1 (显示 YY1 蛋白) meditating and/or regulating the interaction of OCT4 (显示 POU5F1 蛋白) and SOX2 at a posttranscriptional level.
The results revealed that the synthesized complex decoy can concomitantly target Sox2 and Oct4 (显示 POU5F1 蛋白), which subsequently represses the stemness properties of mESCs compared to controls through decreasing cell viability, arresting cell cycle in G0 /G1 phases, inducing apoptosis, and modulating differentiation in mESCs despite the presence of 2i/LIF (显示 LIF 蛋白) in cell culture.
Sox2 activity is crucial for the induction of the neural progenitor gene Hes5 (显示 HES5 蛋白) and for subsequent differentiation of the neuronal lineage.
Deletion of Sox2 specifically in Sox2(+) cells during incisor renewal revealed cellular plasticity that leads to the relatively rapid restoration of a Sox2-expressing cell population.
these findings show that sox2 and sox3 (显示 SOX3 蛋白) are together required for proper otic induction, but the level of expression must be tightly regulated to avoid suppression of differentiation and maintenance of pluripotency.
these data show that sox2 and sox3 (显示 SOX3 蛋白) exhibit intrinsic differences in promoting sensory vs. neural competence, but at high levels these factors can mimic each other to enhance both states. Regional cofactors like pax2a and fgf8 (显示 FGF8 蛋白) also modify sox2/3 functions.
Findings indicate a pivotal role for ZNF32 (显示 ZNF32 蛋白) function in SOX2 expression and regeneration regulation.
Both sox2 and p27kip are regulated by the retinoic acid signal pathway and are essential for hair cell regeneration.
a role of Sox2 as one of the proliferation initiators in ependymal cells after spinal cord injury
Sox2 is identified as the unknown factor responsible for pineal photoreceptor prepatterning and performs this function independently of the BMP signaling.
significant decreases in sox2 (up to 4-fold) expression following chilling and increase of sox2 (up to 3-fold) during warming of chilled embryos.
Knockdown of the four B1 sox (显示 PIPOX 蛋白) genes sox2/3/19a/19b resulted in severe developmental abnormalities.
sox2 is required for hair cell survival, as well as for transdifferentiation of support cells into hair cells during regeneration
shows the occurrence and cell localization of the Sox-2 in chemosensory and mechanosensory organs of zebrafish during the embryonic stage to adult, suggest an involvement of Sox-2 in cell renewal of zebrafish sensory organs
Sox2 is necessary for spinal cord regeneration and suggest a model whereby spinal cord injury activates proliferation of Sox2/3 expressing cells and their differentiation into neurons, a mechanism that is lost in non-regenerative froglets.
Tail amputation results in a global increase of Sox2 levels and proliferation of Sox2-positive cells after spinal cord injury.
Data indicate that pluripotency genes sox2, p63 and oct60 are upregulated early during the process of lens regeneration.
Suggest that SOX2 directly upregulates FGF8 (显示 FGF8 蛋白) gene expression in the early embryonic development of Xenopus.
Continuous expression of Sox1 (显示 SOX1 蛋白) and Sox2 in transgenic embryos represses neuron differentiation and inhibits anterior development while increasing cell proliferation.
direct interaction and interdependence between the Otx2 (显示 OTX2 蛋白) and Sox2 proteins coordinate Rax (显示 RAX 蛋白) expression in eye development, providing molecular linkages among the genes responsible for ocular malformation.
Sox3 functions as an activator to induce expression of the early neural genes, sox2 and geminin in the absence of protein synthesis and to indirectly inhibit the Bmp target Xvent2
A directional Wnt (显示 WNT2 蛋白)/beta-catenin (显示 CTNNB1 蛋白)-Sox2-proneural pathway regulates the transition from proliferation to differentiation in the retina.
Sox2 has a role in pluripotency in pig embryos
Overexpression of Sox2 or Oct4 (显示 POU5F1 蛋白) in bone mesenchymal stem cells in culture media containing a basic fibroblast growth factor (显示 FGF2 蛋白) results in higher proliferation and differentiation compared to controls.
cells isolated from umbilical cord express three transcription factors,Oct-4, Sox-2 & Nanog, found in pluripotent stem cell markers both at the mRNA and protein level
NANOG (显示 NANOG 蛋白) and SOX2 expression inversely correlated with the DNA methylation (显示 HELLS 蛋白) pattern in the promoter region
This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT).
SRY-related HMG-box gene 2
, transcription factor SOX-2
, transcription factor SOX2
, SRY-box containing gene 2
, SRY-box 2
, SRY-related HMG-box 2
, sex determining region Y-box 2
, SRY (sex determining region Y)-box 2
, transcription factor Sox-2
, sex-determining region Y-box 2
, Sox2 transcription factor
, delta EF2a
, LOW QUALITY PROTEIN: transcription factor SOX-2