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Study generated a transgenic rat model that overexpresses the mouse DAT (显示 SLC6A3 抗体) gene via pronuclear microinjection. These rats specifically exhibited behavioral and pharmaco-therapeutic phenotype of repetitive disorders. Together, findings suggest that the DAT (显示 SLC6A3 抗体) rat model will constitute a valuable tool for studying the pathological role of DAT (显示 SLC6A3 抗体) overexpression on neural systems relevant to relevant to neuropsychiatric disorders.
The findings of thuis study indicated that the DAT (显示 SLC6A3 抗体) Val559 variant induces impulsivity behaviors that are dependent upon the reward context, with increased impulsive action observed when mice are required to delay responding for a reward.
These results suggest that DAT (显示 SLC6A3 抗体) expression affects TH expression and phosphorylation largely in DA terminal field compartments.
These behavioral and molecular phenotypes indicate that a genetic-driven DAT (显示 SLC6A3 抗体) hypofunction alters neurodevelopmental trajectories consistent with ADHD, but not with schizophrenia and bipolar disorders.
An exquisite microanatomical regulation of dopamine by the dopamine transporter was identified in striosomes relative to the matrix in the corpus striatum.
Data suggest that environment pollutants methylmercury and 1-methyl-4-phenylpyridinium decrease release of dopamine from dopaminergic neurons; this mechanism involves down-regulation of expression of Slc6a3 (显示 SLC6A3 抗体).
This study show that Dopamine transporter is enriched in filopodia and induces filopodia formation.
The sigma-1R deficiency through suppressing NR2B (显示 GRIN2B 抗体) function and DAT (显示 SLC6A3 抗体) expression can reduce MPTP (显示 PTPN2 抗体)-induced death of dopaminergic neurons and parkinsonism.
DAT (显示 SLC6A3 抗体) gene knockout in mice results dendritic spine loss in pyramidal neurons in the CA1 (显示 CA1 抗体) field of the hippocampus.
Results show that moderate increases in DAT (显示 SLC6A3 抗体) function cause spontaneous dopaminergic cell loss, oxidative stress and fine motor impairment that is reversed by l-DOPA treatment
From all the statistically significant CpGs, methylation levels of cg00997378 (SLC6A3 (显示 SLC6A3 抗体) gene) showed the highest differences (p < 0.0001), being associated with prematurity risk factors. SLC6A3 (显示 SLC6A3 抗体) methylation, previously related to attention-deficit/hyperactivity disorder, neuronal function and behavior, might be a potential epigenetic biomarker with value in the early diagnosis and management of neurodevelopmenta
Results show that Gbetagamma activation regulates DAT (显示 SLC6A3 抗体) activity by increasing dopamine (DA) efflux, and suggests that Gbetagamma promotes an efflux-willing state of the transporter and that the activation of a GPCR (显示 NMUR1 抗体) can lead to a Gbetagamma-dependent DA efflux. Furthermore, the cellular responses that occur following activation of a Galphaq (显示 GNAQ 抗体)-coupled receptor are the result of multiple signaling pathways mediated by Galpha (显示 SUCLG1 抗体)...
Findings demonstrate that histidine547 on hDAT plays a crucial role in stabilizing basal dopamine transport and Tat (显示 TAT 抗体)-DAT (显示 SLC6A3 抗体) interaction.
In a study of the genetic association between polymorphisms in the DAT1, SERT (显示 SLC6A4 抗体), COMT (显示 COMT 抗体) and BDNF (显示 BDNF 抗体) genes and attention deficit and hyperactive disorder, transmission disequilibrium test analysis showed that no individual allele of any variant studied has a preferential transmission.
SLC6A3 (显示 SLC6A3 抗体) repeat allele was higher proportion in Indonesian children with ADHD than healthy controls.
This study demonstrate the genetic influence of a family history of alcohol use disorders and DAT (显示 SLC6A3 抗体) and DBH (显示 DBH 抗体) gene polymorphisms on the risk of withdrawal seizures and delirium tremens.
Multilevel models revealed that history of care had a greater influence on maternal baseline cortisol(but not cortisol trajectory)for mothers with more plasticity alleles of SLC6A3 (显示 SLC6A3 抗体) and OXTR (显示 OXTR 抗体), relative to mothers with fewer or no plasticity alleles. Findings indicate that a mother's history of care is related to her cortisol secretion in anticipation of infant stress, but this relation depends on her genetic characteristics
This combined computational-experimental study demonstrates that histidine-547 (H547) of human DAT (显示 SLC6A3 抗体) plays a crucial role in the DAT (显示 SLC6A3 抗体)-HIV-1 Tat (显示 TAT 抗体) binding and dopamine uptake by DAT (显示 SLC6A3 抗体).
The subjective responses to alcohol consumption in social drinkers were associated with significant epistatic interactions between OPRM1 (显示 OPRM1 抗体) and DAT1 genotypes.
case-control study by genotyping 7 SNPs of SLC6A2 (显示 SLC6A2 抗体), SLC6A3 (显示 SLC6A3 抗体) and DRD2 (显示 DRD2 抗体) in 1034 schizophrenia patients and 1034 controls. No significant difference in the allelic or genotypic frequency was detected between cases and controls
This gene encodes a dopamine transporter which is a member of the sodium- and chloride-dependent neurotransmitter transporter family. The 3' UTR of this gene contains a 40 bp tandem repeat, referred to as a variable number tandem repeat or VNTR, which can be present in 3 to 11 copies. Variation in the number of repeats is associated with idiopathic epilepsy, attention-deficit hyperactivity disorder, dependence on alcohol and cocaine, susceptibility to Parkinson disease and protection against nicotine dependence.
, dopamine transporter 1
, sodium-dependent dopamine transporter
, solute carrier family 6 member 3
, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3
, LIM domain only protein 3
, LIM domain only 3
, neuronal-specific transcription factor DAT1
, dopamine-inducible LIM-domain transcription factor DAT1
, LIM domain only protein 1