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|抗原||PMS2 Postmeiotic Segregation Increased 2 (S. Cerevisiae) (PMS2) 抗体|
|抗原表位||AA 623-639 其他选择|
|适用||人, 小鼠 其他选择|
|标记||This PMS2 antibody is un-conjugated 其他选择|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
PMS2抗体详情PMS2目标详情 使用细节 贮存及处理 图像
|特异性||Recognizes Postmeiotic Segregation Increased 2 (PMS2).|
Species reactivity (expected):Mouse.
Species reactivity (tested):Human.
|产品特性||Synonyms: PMSL2, PMS-2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, DNAmismatch repair protein PMS2|
|纯化方法||Protein G Chromatography.|
|免疫原||Synthetic peptide (KLH conjugated) corresponding to amino acids 623-639 of HumanPMS2. AA Sequence: SSLAKRIKQLHHEAQQS|
|Plasmids, Primers & others|
PMS2目标详情PMS2抗体详情 使用细节 贮存及处理 图像 回页首
|别名||PMS2 (PMS2 Antibody 摘要)|
|背景||Mismatch DNA repair in bacteria is carried out by the MutL, MutH, and MutS proteins. The MutS protein initially bunds to mismatched DNA. This is followed by binding of the MutH endonuclease and MutL to form a complex that carries out excision repair. The hMSH2 gene specifies a MutS homologue and hMLH1, hPMS1, and hPMS2 encode MutL homologs. Mutations in these genes are associated with hereditary nonpolyposis colon cancer (HNPCC), one of the most common hereditary diseases in man. As with the bacterial system, HNPCC is characterized by frequent microsatellite mutations that arise by somatic mutation due to a replication error (RER+) phenotype. Both hPMS1 and hPMS2 are mutated in the germline of HNPCC patients. Although the exact function of MutL and its homologs has yet to be determined, it is known that a complex of PMS2 and MLH1 (MutLa) from HeLa cells can complement a deficiency of MLH1 in hypermutable H6 colorectal tumor cells.Synonyms: DNA mismatch repair protein PMS2, Mismatch repair endonuclease PMS2, PMS1 protein homolog 2, PMSL2|
|途径||DNA Damage Repair, Production of Molecular Mediator of Immune Response|
使用细节PMS2抗体详情 PMS2目标详情 贮存及处理 图像 回页首
Western blot: 1-2 μg/mL. Immunohistochemistry on Paraffin Sections: 5 μg/mL. In IHC with FFPE tissues this antibody shows staining of Mucin in Colon in addition to theexpected signal.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
贮存及处理PMS2抗体详情 PMS2目标详情 使用细节 图像 回页首
|缓冲液||PBS containing 0.02 % Sodium Azide as preservative.|
|注意事项||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|储存条件||4 °C/-20 °C|
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Shelf life: one year from despatch.
图像PMS2抗体详情 PMS2目标详情 使用细节 贮存及处理 回页首