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DNMT3L 产品

(DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

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CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].

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Featured DNMT3L Categories

DNMT3L 抗体

High quality antibodies with extensive validation data.

DNMT3L ELISA试剂盒

Reliable ELISA kits for a wide range of species.

DNMT3L 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DNMT3L 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, IP
Validations
  • (5)
Cat. No. ABIN526180
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, ICC, FACS
Validations
  • (5)
Cat. No. ABIN5542515
Quantity 0.1 mg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (4)
Cat. No. ABIN7260352
Quantity 200 μL
Datasheet Datasheet

Recommended DNMT3L ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960699
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
Cat. No. ABIN4993275
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method Quantitative
Validations
Cat. No. ABIN2947075
Quantity 96 tests
Datasheet Datasheet

Recommended DNMT3L 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122681
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN7122680
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351873
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our DNMT3L Products

Das, Chai, Kim, Lee, Park, Jung, Chai: "Transcriptome sequencing of microglial cells stimulated with TLR3 and TLR4 ligands." in: BMC genomics, Vol. 16, pp. 517, (2016) (PubMed).

Satterlee, Beckel-Mitchener, McAllister, Procaccini, Rutter, Tyson, Chadwick: "Community resources and technologies developed through the NIH Roadmap Epigenomics Program." in: Methods in molecular biology (Clifton, N.J.), Vol. 1238, pp. 27-49, (2014) (PubMed).

Bonnin, Belville, Chiambaretta, Sapin, Blanchon: "DNA methyl transferases are differentially expressed in the human anterior eye segment." in: Acta ophthalmologica, Vol. 92, Issue 5, pp. e366-71, (2014) (PubMed).

Ajj, Chesnel, Pinel, Plenat, Flament, Dumond: "An alkylphenol mix promotes seminoma derived cell proliferation through an ERalpha36-mediated mechanism." in: PLoS ONE, Vol. 8, Issue 4, pp. e61758, (2013) (PubMed).

Yu, Thieu, Kaplan: "Stat4 limits DNA methyltransferase recruitment and DNA methylation of the IL-18Ralpha gene during Th1 differentiation." in: The EMBO journal, Vol. 26, Issue 8, pp. 2052-60, (2007) (PubMed).

Deplus, Brenner, Burgers, Putmans, Kouzarides, de Launoit, Fuks: "Dnmt3L is a transcriptional repressor that recruits histone deacetylase." in: Nucleic acids research, Vol. 30, Issue 17, pp. 3831-8, (2002) (PubMed).

Chedin, Lieber, Hsieh: "The DNA methyltransferase-like protein DNMT3L stimulates de novo methylation by Dnmt3a." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16916-21, (2002) (PubMed).

Kierszenbaum: "Genomic imprinting and epigenetic reprogramming: unearthing the garden of forking paths." in: Molecular reproduction and development, Vol. 63, Issue 3, pp. 269-72, (2002) (PubMed).

Okazaki, Furuno, Kasukawa, Adachi, Bono, Kondo, Nikaido, Osato, Saito, Suzuki, Yamanaka, Kiyosawa, Yagi, Tomaru, Hasegawa, Nogami, Schönbach, Gojobori, Baldarelli, Hill, Bult, Hume, Quackenbush et al.: "Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. ..." in: Nature, Vol. 420, Issue 6915, pp. 563-73, (2002) (PubMed).

Aapola, Lyle, Krohn, Antonarakis, Peterson: "Isolation and initial characterization of the mouse Dnmt3l gene." in: Cytogenetics and cell genetics, Vol. 92, Issue 1-2, pp. 122-6, (2001) (PubMed).

Synonyms and alternative names related to DNMT3L

DNA methyltransferase 3 like (DNMT3L), DNA (cytosine-5-)-methyltransferase 3-like (Dnmt3l), DNA methyltransferase 3 like (Dnmt3l), D6Ertd14e, DNMT3L, ecat7

Protein level used designations for DNMT3L

  • DNA (cytosine-5-)-methyltransferase 3-like
  • cytosine-5-methyltransferase 3-like protein
  • DNA (cytosine-5)-methyltransferase 3-like
  • human cytosine-5-methyltransferase 3-like protein
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