DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008].
Zhang, Kim, Bao, Facchinetti, Jung, Ghaffari, Qin, Cheng, Liu: "DDX1, DDX21, and DHX36 helicases form a complex with the adaptor molecule TRIF to sense dsRNA in dendritic cells." in: Immunity, Vol. 34, Issue 6, pp. 866-78, (2011) (PubMed).
Grundhoff, Kremmer, Türeci, Glieden, Gindorf, Atz, Mueller-Lantzsch, Schubach, Grässer: "Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C." in: The Journal of biological chemistry, Vol. 274, Issue 27, pp. 19136-44, (1999) (PubMed).
Godbout, Packer, Bie: "Overexpression of a DEAD box protein (DDX1) in neuroblastoma and retinoblastoma cell lines." in: The Journal of biological chemistry, Vol. 273, Issue 33, pp. 21161-8, (1998) (PubMed).
Amler, Schürmann, Schwab: "The DDX1 gene maps within 400 kbp 5' to MYCN and is frequently coamplified in human neuroblastoma." in: Genes, chromosomes & cancer, Vol. 15, Issue 2, pp. 134-7, (1996) (PubMed).
Squire, Thorner, Weitzman, Maggi, Dirks, Doyle, Hale, Godbout: "Co-amplification of MYCN and a DEAD box gene (DDX1) in primary neuroblastoma." in: Oncogene, Vol. 10, Issue 7, pp. 1417-22, (1995) (PubMed).