DDR1 抗体
(Discoidin Domain Receptor tyrosine Kinase 1 (DDR1))
Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2011].
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Latest Publications for our DDR1 抗体
: "Targeting of DDR1 with antibody-drug conjugates has antitumor effects in a mouse model of colon carcinoma." in: Molecular oncology, (2019) (PubMed).: "Normal activation of discoidin domain receptor 1 mutants with disulfide cross-links, insertions, or deletions in the extracellular juxtamembrane region: mechanistic implications." in: The Journal of biological chemistry, Vol. 289, Issue 19, pp. 13565-74, (2014) (PubMed).
: "Activated hair follicle stem cells and Wnt/?-catenin signaling involve in pathnogenesis of sebaceous neoplasms." in: International journal of medical sciences, Vol. 11, Issue 10, pp. 1022-8, (2014) (PubMed).
: "A unique and potent protein binding nature of liposome containing polyethylenimine and polyethylene glycol: a nondisplaceable property." in: Biotechnology and bioengineering, Vol. 108, Issue 6, pp. 1318-27, (2011) (PubMed).
: "Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis." in: BMC cancer, Vol. 7, pp. 55, (2007) (PubMed).
: "Sensing extracellular matrix: an update on discoidin domain receptor function." in: Cellular signalling, Vol. 18, Issue 8, pp. 1108-16, (2006) (PubMed).
: "Professional practice solutions.... How does a healthcare organization deal with conflicting directives between HCFA regulations and Joint Commission standards when obligated to abide by both?" in: Journal of AHIMA / American Health Information Management Association, Vol. 72, Issue 7, pp. 87-8, (2005) (PubMed).
: "Discoidin domain receptor (DDR) 1 and 2: collagen-activated tyrosine kinase receptors in the cornea." in: Experimental eye research, Vol. 72, Issue 1, pp. 87-92, (2001) (PubMed).
: "Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 14, Issue 7, pp. 973-81, (2000) (PubMed).
: "Discoidin domain receptor 1 functions in axon extension of cerebellar granule neurons." in: Genes & development, Vol. 14, Issue 17, pp. 2216-28, (2000) (PubMed).
Aliases for DDR1 抗体
Discoidin domain receptor (Ddr) 抗体discoidin domain receptor family, member 1 (Ddr1) 抗体
discoidin domain receptor tyrosine kinase 1 (DDR1) 抗体
discoidin domain receptor tyrosine kinase 1 (Ddr1) 抗体
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