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DAD1 产品

(Defender Against Cell Death 1 (DAD1))
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008].

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Featured DAD1 Categories

DAD1 抗体

High quality antibodies with extensive validation data.

DAD1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

DAD1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DAD1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7150599
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA
Validations
  • (1)
Cat. No. ABIN514863
Quantity 50 μg
Datasheet Datasheet
Reactivity Human
Application WB, IF
Validations
  • (1)
Cat. No. ABIN7266720
Quantity 100 μL
Datasheet Datasheet

Recommended DAD1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1130573
Quantity 96 tests
Datasheet Datasheet
Reactivity Rat
Analytical Method
Validations
Cat. No. ABIN1130575
Quantity 96 tests
Datasheet Datasheet
Reactivity Pig
Analytical Method
Validations
Cat. No. ABIN1130574
Quantity 96 tests
Datasheet Datasheet

Recommended DAD1 蛋白

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Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351076
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3098984
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
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  • (1)
Cat. No. ABIN3120718
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our DAD1 Products

Espinoza, Scarpato, Damiani, Managò, Mereu, Contestabile, Peruzzo, Carninci, Santoro, Papaleo, Mingozzi, Ronzitti, Zucchelli, Gustincich: "SINEUP Non-coding RNA Targeting GDNF Rescues Motor Deficits and Neurodegeneration in a Mouse Model of Parkinson's Disease." in: Molecular therapy : the journal of the American Society of Gene Therapy, (2019) (PubMed).

Li, Moore, Vasilieva, Sui, Wong, Berne, Somasundaran, Sullivan, Luzuriaga, Greenough, Choe, Farzan: "Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus." in: Nature, Vol. 426, Issue 6965, pp. 450-4, (2003) (PubMed).

Crackower, Sarao, Oudit, Yagil, Kozieradzki, Scanga, Oliveira-dos-Santos, da Costa, Zhang, Pei, Scholey, Ferrario, Manoukian, Chappell, Backx, Yagil, Penninger: "Angiotensin-converting enzyme 2 is an essential regulator of heart function." in: Nature, Vol. 417, Issue 6891, pp. 822-8, (2002) (PubMed).

Pagano: "Vascular gp91(phox): beyond the endothelium." in: Circulation research, Vol. 87, Issue 1, pp. 1-3, (2000) (PubMed).

Tipnis, Hooper, Hyde, Karran, Christie, Turner: "A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase." in: The Journal of biological chemistry, Vol. 275, Issue 43, pp. 33238-43, (2000) (PubMed).

Sanjay, Fu, Kreibich: "DAD1 is required for the function and the structural integrity of the oligosaccharyltransferase complex." in: The Journal of biological chemistry, Vol. 273, Issue 40, pp. 26094-9, (1998) (PubMed).

Kelleher, Gilmore: "DAD1, the defender against apoptotic cell death, is a subunit of the mammalian oligosaccharyltransferase." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 10, pp. 4994-9, (1997) (PubMed).

Steller: "Mechanisms and genes of cellular suicide." in: Science (New York, N.Y.), Vol. 267, Issue 5203, pp. 1445-9, (1995) (PubMed).

Nakashima, Sekiguchi, Kuraoka, Fukushima, Shibata, Komiyama, Nishimoto: "Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells." in: Molecular and cellular biology, Vol. 13, Issue 10, pp. 6367-74, (1993) (PubMed).

Synonyms and alternative names related to DAD1

dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1 (LOC100115214), defender against cell death 1 (DAD1), defender against cell death 1 (dad1), defender against cell death 1 (CC1G_00458), defender against cell death 1 (CpipJ_CPIJ003512), hypothetical protein (PGTG_09898), defender against cell death 1 (Dad1), defender against cell death 1 S homeolog (dad1.S), Defender against death (DAD family) protein (ATDAD1), false DAD1 (fdad1), Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad-1 (dad-1), AI323713, DAD-1, dad1, DAD1, DEFENDER AGAINST APOPTOTIC DEATH 1, F3C3.14, F3C3_14, NV18456, ost2, OST2, si:ch211-9d9.5

Protein level used designations for DAD1

  • dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
  • DAD-1
  • oligosaccharyl transferase subunit DAD1
  • Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
  • defender against cell death 1
  • oligosaccharyltransferase 2 homolog
  • oligosaccharyltransferase subunit 2 (non-catalytic)
  • defender against death (DAD1)
  • apoptotic suppressor
  • defender against cell death 1 protein
  • defender against death protein 1
  • defender against apoptotic cell death
  • dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit dad1
  • oligosaccharyl transferase subunit dad1
  • Oligosaccharyl transferase subunit DAD1
  • false DAD1
  • CL0_-2
  • gpm673
  • QCJ15g11
  • CL0_-2_ov
  • p-QCJ15g11
  • AY109816_IDP
  • gnp_QCJ15g11
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