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DAAM1 产品

(Dishevelled Associated Activator of Morphogenesis 1 (DAAM1))
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012].

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Featured DAAM1 Categories

DAAM1 抗体

High quality antibodies with extensive validation data.

DAAM1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

DAAM1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended DAAM1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
  • (5)
Cat. No. ABIN564982
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, PLA
Validations
  • (6)
Cat. No. ABIN524909
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7238873
Quantity 200 μL
Datasheet Datasheet

Recommended DAAM1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method
Validations
Cat. No. ABIN1129869
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1129870
Quantity 96 tests
Datasheet Datasheet

Recommended DAAM1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1351055
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7418875
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3092047
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our DAAM1 Products

Nishimura, Ito, Saito, Hiver, Shigetomi, Ikenouchi, Takeichi: "DAAM1 stabilizes epithelial junctions by restraining WAVE complex-dependent lateral membrane motility." in: The Journal of cell biology, Vol. 215, Issue 4, pp. 559-573, (2017) (PubMed).

Molnár, Migh, Szikora, Kalmár, Végh, Deák, Barkó, Bugyi, Orfanos, Kovács, Juhász, Váró, Nyitrai, Sparrow, Mihály: "DAAM is required for thin filament formation and Sarcomerogenesis during muscle development in Drosophila." in: PLoS genetics, Vol. 10, Issue 2, pp. e1004166, (2014) (PubMed).

Su, Mendoza, Kwak, Bayless: "Molecular profile of endothelial invasion of three-dimensional collagen matrices: insights into angiogenic sprout induction in wound healing." in: American journal of physiology. Cell physiology, Vol. 295, Issue 5, pp. C1215-29, (2008) (PubMed).

Liu, Sato, Khadka, Bharti, Diaz, Runnels, Habas: "Mechanism of activation of the Formin protein Daam1." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 210-5, (2008) (PubMed).

Kida, Sato, Miyasaka, Suto, Ogura: "Daam1 regulates the endocytosis of EphB during the convergent extension of the zebrafish notochord." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 104, Issue 16, pp. 6708-13, (2007) (PubMed).

Lu, Meng, Poy, Maiti, Goode, Eck: "Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly." in: Journal of molecular biology, Vol. 369, Issue 5, pp. 1258-69, (2007) (PubMed).

Yamashita, Higashi, Suetsugu, Sato, Ikeda, Shirakawa, Kita, Takenawa, Horiuchi, Fukai, Nureki: "Crystal structure of human DAAM1 formin homology 2 domain." in: Genes to cells : devoted to molecular & cellular mechanisms, Vol. 12, Issue 11, pp. 1255-65, (2007) (PubMed).

Synonyms and alternative names related to DAAM1

dishevelled associated activator of morphogenesis 1 (DAAM1), dishevelled associated activator of morphogenesis 1 (Daam1), dishevelled associated activator of morphogenesis 1 S homeolog (daam1.S), dishevelled associated activator of morphogenesis 1a (daam1a), dishevelled associated activator of morphogenesis 1 (daam1), dishevelled associated activator of morphogenesis 1b (daam1b), 1700066F09Rik, 2310028E21Rik, AI503486, daam-1, daam1, DAAM1, daam1l, DKFZp468D0524, E130308H01, fc83b10, mKIAA0666, si:ch211-87i20.1, wu:fc83b10, xdaam1

Protein level used designations for DAAM1

  • disheveled-associated activator of morphogenesis 1
  • dishevelled associated activator of morphogenesis 1
  • dishevelled-associated activator of morphogenesis 1
  • disheveled-associated activator of morphogenesis 1-like
  • dishevelled associated activator of morphogenesis 1, like
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