Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks. {ECO:0000269|PubMed:14609959}.
Latest Publications for our Crossover junction endonuclease EME1 抗体
Vigneron, Gamelin, Coqueret: "The EGFR-STAT3 oncogenic pathway up-regulates the Eme1 endonuclease to reduce DNA damage after topoisomerase I inhibition." in: Cancer research, Vol. 68, Issue 3, pp. 815-25, (2008) (PubMed).
Taylor, McGowan: "Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 10, pp. 3757-62, (2008) (PubMed).
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks." in: Cell, Vol. 127, Issue 3, pp. 635-48, (2006) (PubMed).
Aliases for Crossover junction endonuclease EME1 抗体