(C-Type Lectin Domain Family 4, Member E (CLEC4E))
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type II transmembrane protein is a downstream target of CCAAT/enhancer binding protein (C/EBP), beta (CEBPB) and may play a role in inflammation. Alternative splice variants have been described but their full-length sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008].
Ndiaye, Brauner, Flytzani, Kular, Warnecke, Adzemovic, Piket, Min, Edwards, Mela, Choi, Magg, James, Linden, Reichardt, Daws, van Horssen, Kockum, Harris, Olsson, Guerreiro-Cacais, Jagodic: "C-type lectin receptors Mcl and Mincle control development of multiple sclerosis-like neuroinflammation." in: The Journal of clinical investigation, (2020) (PubMed).
An, Schneller, Frassetto, Liang, Zhu, Park, Theisen, Hong, Zhou, Rajendran, Levy, Howell, Besin, Presnyak, Sabnis, Murphy-Benenato, Kumarasinghe, Salerno, Mihai, Lukacs, Chandler, Guey, Venditti et al.: "Systemic Messenger RNA Therapy as a Treatment for Methylmalonic Acidemia. ..." in: Cell reports, Vol. 21, Issue 12, pp. 3548-3558, (2018) (PubMed).
de Rivero Vaccari, Brand, Berti, Alonso, Bullock, de Rivero Vaccari: "Mincle signaling in the innate immune response after traumatic brain injury." in: Journal of neurotrauma, Vol. 32, Issue 4, pp. 228-36, (2015) (PubMed).
He, Xu, Li, Guo, Hu, Guo, Tang, Chen, Zhang, Tang, Zhang: "Macrophage-Inducible C-Type Lectin/Spleen Tyrosine Kinase Signaling Pathway Contributes to Neuroinflammation After Subarachnoid Hemorrhage in Rats." in: Stroke, Vol. 46, Issue 8, pp. 2277-86, (2015) (PubMed).
Kawata, Illarionov, Yang, Kenny, Zhang, Tsuda, Ando, Leung, Ansari, Eric Gershwin: "Mincle and human B cell function." in: Journal of autoimmunity, Vol. 39, Issue 4, pp. 315-22, (2012) (PubMed).
C-type lectin domain family 4 member E (CLEC4E) 抗体 C-type lectin domain family 4, member e (Clec4e) 抗体 C-type lectin domain family 4, member E (Clec4e) 抗体 C-type lectin domain family 4 member E (LOC611538) 抗体 C-type lectin domain family 4 member E (Clec4e) 抗体 C86253 抗体 CLEC4E 抗体 CLECSF9 抗体 Clecsf9 抗体 MINCLE 抗体 Mincle 抗体