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Human FOXP3 Protein expressed in Wheat germ - ABIN1354393
Liu, Liu, Chen, Yang, Liu, Liu, Dugas, Tang, Zheng, Liu, Wang: FOXP3 Controls an miR-146/NF-?B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. in Cancer research 2015
Human FOXP3 Protein expressed in HEK-293 Cells - ABIN2721384
Larsen, Munir, Woetmann, Frøsig, Odum, Svane, Becker, Andersen: Functional characterization of Foxp3-specific spontaneous immune responses. in Leukemia 2013
analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish
correlation between the expression of t-bet, stat6 (显示 STAT6 蛋白) and foxp3 with other genes involved in Th and T(reg (显示 KCNH2 蛋白)) responses
cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals
Studied lymphocyte phenotype in resected lymph nodes of patients with lung cancer by analyzing levels of Foxp3 and CD8 (显示 CD8A 蛋白) by immunohistochemical staining.
We conclude that Foxp3 promoter polymorphisms are associated with susceptibility to endometrial cancer in Chinese Han women.
Studied the association between Foxp3 gene polymorphisms and the susceptibility to differentiated thyroid cancers in a Chinese Han population.
DLBCL cases with high FOXP3 have longer survival (P=0.03). T cells in the background of DLBCL may play a role in modulation of tumor progression. Their presence is associated with favorable prognostic parameters in DLBCL
no significant association between rs3761548, rs2232365 polymorphisms of the FOXP3 gene, and an increased susceptibility to allergic rhinitis [meta-analysis]
Zinc is capable of ameliorating the allogeneic immune reaction by enhancement of antigen-specific iTreg cells due to modulation of essential molecular targets by upregulation of Foxp3 and KLF-10 and downregulation of IRF-1 (显示 IRF1 蛋白).
The Foxp3+ regulatory T cells (Tregs) play an indispensable role in controlling tolerance and immunity against self- and foreign antigens.
study highlights the role of tissue differentiation on pathological response to neoadjuvant chemotherapy in gastric cancer and shows no impact between FOXP3, HER2 (显示 ERBB2 蛋白) and MET expression in terms of tumor regression grading
Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
FOXP3 genotype association with breast cancer susceptibility and outcome depends on the breast cancer subtype.
the findings suggested that excreted-secreted antigens restricted Foxp3 expression by inhibiting TGFssRII/Smad2 (显示 SMAD2 蛋白)/Smad3 (显示 SMAD3 蛋白)/Smad4 (显示 SMAD4 蛋白) signalling, ultimately resulting in abortion.
Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 (显示 CD44 蛋白) in co-cultures of dendritic cells and CD4 (显示 CD4 蛋白)+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 (显示 CD44 蛋白) = homing receptor)
Dendritic cells have the capacity to express Foxp3, which can be upregulated by exposure to Staphylococcal enterotoxin B.
the Treg transcription factor Foxp3 reprograms T cell metabolism by suppressing Myc (显示 MYC 蛋白) and glycolysis, enhancing oxidative phosphorylation, and increasing nicotinamide adenine dinucleotide oxidation.
Data suggest that genetic or environmental factors that even moderately affect the expression of both PD-1 (显示 PDCD1 蛋白) and FoxP3 can cause life-threatening autoimmune diseases by disrupting the T-cell homeostasis.
Control of Regulatory T Cell Development by the Transcription Factor Foxp3.
Foxp3 Programs the Development and Function of CD4 (显示 CD4 蛋白)+CD25 (显示 IL2RA 蛋白)+ Regulatory T Cells.
An Essential Role for Scurfin in CD4 (显示 CD4 蛋白)+CD25 (显示 IL2RA 蛋白)+ T Regulatory Cells.
Mechanistic analysis indicated that E47 (显示 TCF3 蛋白) activated expression of the transcription factor Spi-B (显示 SPIB 蛋白) and the suppressor of cytokine signaling 3 (SOCS3 (显示 SOCS3 蛋白)), which both downregulated Foxp3 expression. These findings demonstrate that the balance of Id3 (显示 ID3 蛋白) and E47 (显示 TCF3 蛋白) controls the maintenance of Foxp3 expression in Treg cells and, thus, contributes to Treg cell plasticity.
sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids
In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection
GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4 (显示 CTLA4 蛋白).
The expression of Foxp3 in CD4 (显示 CD4 蛋白)(+) T cells from persistent lymphocytotic cattle was significantly increased.
There is a positive correlation between the intensity of CD25 (显示 IL2RA 蛋白) expression and the expression of the transcription Foxp3 factor in bovine CD8 (显示 CD8A 蛋白)(+) cells.
identification of Foxp3 expression in Treg cells
These findings revealed that despite the existence of a distinct bovine CD4 (显示 CD4 蛋白)(+)CD25 (显示 IL2RA 蛋白)(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
The correlation of TH17-related TLR4 (显示 TLR4 蛋白) expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.
Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.
results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
forkhead box protein P3
, regulatory protein Foxp3
, forkhead box P3
, forkhead box protein P3-like
, transcription factor foxp3
, immune dysregulation, polyendocrinopathy, enteropathy, X-linked
, immunodeficiency, polyendocrinopathy, enteropathy, X-linked
, forkhead/winged helix transcription factor 3