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Human FOXP3 Protein expressed in Wheat germ - ABIN1354393
Liu, Liu, Chen, Yang, Liu, Liu, Dugas, Tang, Zheng, Liu, Wang: FOXP3 Controls an miR-146/NF-?B Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells. in Cancer research 2015
Human FOXP3 Protein expressed in HEK-293 Cells - ABIN2721384
Larsen, Munir, Woetmann, Frøsig, Odum, Svane, Becker, Andersen: Functional characterization of Foxp3-specific spontaneous immune responses. in Leukemia 2013
analysis of Foxp3-based immunoregulation and autoimmunity in zebrafish
correlation between the expression of t-bet, stat6 (显示 STAT6 蛋白) and foxp3 with other genes involved in Th and T(reg (显示 KCNH2 蛋白)) responses
cloning and characterization of the full-length cDNA of Atlantic salmon Foxp3, which possesses a Forkhead domain, a zinc finger domain and a leucine-zipper domain as its counterpart in mammals
It was concluded that the abnormal expression of endometrial E2A (显示 TCF3 蛋白) existed in mid-secretory endometrium of women with recurrent miscarriage, and there was a positive correlation between E2A (显示 TCF3 蛋白) and FOXP3, and E2A (显示 TCF3 蛋白) and CTLA-4 (显示 CTLA4 蛋白), suggesting the possible regulatory role of E2A (显示 TCF3 蛋白) in endometrium receptivity.
Lymphocytic enteritis associated to celiac disease shows an increase of FOXP3 expression and lymphocytes T-gammadelta that is not detected in other etiologies of enteritis.
Downregulated expression of FOXP3 by siRNA transfection significantly inhibited cell proliferation and enhanced chemosensitivity to cisplatin in A549 lung adenocarcinoma cells.
Foxp3 is associated with lymphangiogenesis of cervical cancer.
Polymorphic marker -3279 C>A of the FOXP3 gene was not associated with the risk of Pulmonary Sarcoidosis patients of Russian ethnicity.
Data show that forkhead box P3 protein (FOXP3) protein not only binds with DNA sequences containing one FKH (显示 FOXA1 蛋白) consensus sequence, but also binds with DNA sequences with two direct repeats of consensus sequences separated by three-nucleotides (DRE3).
Study identifies CCR8 (显示 CCR8 蛋白)+ regulatory T cells (Treg cells) as drivers of immunosuppression and provides compelling evidence of a self-feeding mechanism by which, at an autoimmune site, CCL1 (显示 CCL1 蛋白) produced by FOXp3+ Treg cells upregulates the expression of its own receptor, CCR8 (显示 CCR8 蛋白), on these cells, and potentiates their in vivo proliferation and suppressive activities as driver Treg cells.
our findings suggest that FOXP3 suppresses tumor progression in hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) via TGF-b/Smad2 (显示 SMAD2 蛋白)/3 signaling pathway, highlighting the role of FOXP3 as a prognostic factor and novel target for an optimal therapy against this fatal malignancy
Studied lymphocyte phenotype in resected lymph nodes of patients with lung cancer by analyzing levels of Foxp3 and CD8 (显示 CD8A 蛋白) by immunohistochemical staining.
We conclude that Foxp3 promoter polymorphisms are associated with susceptibility to endometrial cancer in Chinese Han women.
Unexpectedly, although dispensable for FOXP3 expression and for the homeostasis and suppressive function of thymus-derived Treg cells, CREB (显示 CREB1 蛋白) negatively regulates the survival of TGF-beta (显示 TGFB1 蛋白)-induced Treg cells, and deletion of CREB (显示 CREB1 蛋白) resulted in increased FOXP3+ Treg cells in the intestine and protection in a colitis model
This study reports on systematic alanine-scan mutagenesis of FoxP3, assessing mutational impacts on DNA binding and transcriptional activation or repression.
Foxp3 is essential for beneficial outcome of the microglial response and depends upon signalling by the immunoglobulin CD200 (显示 CD200 蛋白) through its receptor (CD200R (显示 CD200R1 蛋白))
Tbet is a critical modulator of FoxP3 expression in autoimmune graft-versus-host disease
Generation of RORgammat(+) antigen-specific T17 regulatory cells from Foxp3(+) precursors in autoimmunity has been described.
KLRG1 (显示 KLRG1 蛋白) expression identifies short-lived Foxp3(+) Treg effector cells with functional plasticity in islets of NOD mice.
Novel regulatory T-cells that are induced by B cells and do not express Foxp3 and IL-10 (显示 IL10 蛋白) alleviate intestinal inflammation in vivo.
the findings suggested that excreted-secreted antigens restricted Foxp3 expression by inhibiting TGFssRII/Smad2 (显示 SMAD2 蛋白)/Smad3 (显示 SMAD3 蛋白)/Smad4 (显示 SMAD4 蛋白) signalling, ultimately resulting in abortion.
Data (including data from studies using transgenic mice) suggest that a single oral dose of vitamin A (1) amplifies tolerogenic activity of dendritic cells migrating to lymphoid tissue and (2) up-regulates expression of Foxp3 and Cd44 (显示 CD44 蛋白) in co-cultures of dendritic cells and CD4 (显示 CD4 蛋白)+ lymphocytes. (Foxp3 = forkhead box P3; Cd44 (显示 CD44 蛋白) = homing receptor)
Flicr, a long noncoding RNA, modulates Foxp3 expression and autoimmunity.
sequenced the entire Foxp3 cDNA which is 1296 nucleotides in length and codes for a polypeptide of 432 amino acids
In a miniature swine lung transplantation model, the FOXP3 mRNA level in the peripheral blood was upregulated at an early phase of rejection
GWAS identified a maternal variant in the upstream region of FOXP3 that was associated with infertility in repeat-breeding Japanese Black cattle that failed to conceive using embryo transfer. The variant affected the level of FOXP3 mRNA expression.
Experimental infection with bovine viral diarrhea virus did not provide evidence ofTreg activation based on expression of FoxP3 and CTLA4 (显示 CTLA4 蛋白).
The expression of Foxp3 in CD4 (显示 CD4 蛋白)(+) T cells from persistent lymphocytotic cattle was significantly increased.
There is a positive correlation between the intensity of CD25 (显示 IL2RA 蛋白) expression and the expression of the transcription Foxp3 factor in bovine CD8 (显示 CD8A 蛋白)(+) cells.
identification of Foxp3 expression in Treg cells
These findings revealed that despite the existence of a distinct bovine CD4 (显示 CD4 蛋白)(+)CD25 (显示 IL2RA 蛋白)(high) T cell population, which showed Foxp3 transcription/expression, natural regulatory activity did not reside in this cell population
The correlation of TH17-related TLR4 (显示 TLR4 蛋白) expression and Foxp3-positive cells in the rectal tissue of horses with inflammatory bowel disease is reported.
Expression levels of FOXP3 mRNA copy numbers were significantly increased in lesional compared to tumour-distant samples. There was no difference in FOXP3 expression in tumour-distant samples from equine sarcoid- compared with control horses.
results confirm FoxP3 expression in the horse, in contrast to the mouse, is regulated similarly to FOXP3 expression in humans and provide evidence that FoxP3 expression by conventional T cells may help regulate the developing immune response
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified.
forkhead box protein P3
, regulatory protein Foxp3
, forkhead box P3
, forkhead box protein P3-like
, transcription factor foxp3
, immune dysregulation, polyendocrinopathy, enteropathy, X-linked
, immunodeficiency, polyendocrinopathy, enteropathy, X-linked
, forkhead/winged helix transcription factor 3