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CHEK1 产品

(Checkpoint Kinase 1 (CHEK1))
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. This protein acts to integrate signals from ATM and ATR, two cell cycle proteins involved in DNA damage responses, that also associate with chromatin in meiotic prophase I. Phosphorylation of CDC25A protein phosphatase by this protein is required for cells to delay cell cycle progression in response to double-strand DNA breaks. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2011].

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Featured CHEK1 Categories

CHEK1 抗体

High quality antibodies with extensive validation data.

CHEK1 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

CHEK1 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CHEK1 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (1)
  • (10)
Cat. No. ABIN6255201
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (1)
  • (12)
Cat. No. ABIN6255160
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (7)
Cat. No. ABIN6255167
Quantity 100 μL
Datasheet Datasheet

Recommended CHEK1 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6954575
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1157195
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4886023
Quantity 96 tests
Datasheet Datasheet

Recommended CHEK1 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect cells (Sf9)
Validations
  • (2)
Cat. No. ABIN5569677
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1349303
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Baculovirus infected Insect Cells
Validations
  • (1)
Cat. No. ABIN7320012
Quantity 50 μg
Datasheet Datasheet

Latest Publications for our CHEK1 Products

Fu, Sun, Xia, Hobbs, Guo, Coulombe, Wan: "Sam68 is required for the growth and survival of nonmelanoma skin cancer." in: Cancer medicine, Vol. 8, Issue 13, pp. 6106-6113, (2019) (PubMed).

Bai, Wang, Huo, Xie, Xie, Xu, Wang: "Serine/Threonine Kinase CHEK1-Dependent Transcriptional Regulation of RAD54L Promotes Proliferation and Radio Resistance in Glioblastoma." in: Translational oncology, Vol. 11, Issue 1, pp. 140-146, (2018) (PubMed).

Ji, Zheng, Liu, Ren, Gao, Zhang, Li: "Resveratrol promotes oxidative stress to drive DLC1 mediated cellular senescence in cancer cells." in: Experimental cell research, Vol. 370, Issue 2, pp. 292-302, (2018) (PubMed).

Jiang, Wang, Xing, Shen, Lian, Yi, Zhang, Yang, Liu, Zhang: "Sterigmatocystin-induced checkpoint adaptation depends on Chk1 in immortalized human gastric epithelial cells in vitro." in: Archives of toxicology, Vol. 91, Issue 1, pp. 259-270, (2017) (PubMed).

Shibata, Kiran, Shibata, Singh, Kiran, Dutta: "Two subunits of human ORC are dispensable for DNA replication and proliferation." in: eLife, Vol. 5, (2017) (PubMed).

Xu, Zhou, Xiong, Zou, Deng, Ganaie, Kleiboeker, Peng, Liu, Wang, Ye, Qiu: "Parvovirus B19 NS1 protein induces cell cycle arrest at G2-phase by activating the ATR-CDC25C-CDK1 pathway." in: PLoS pathogens, Vol. 13, Issue 3, pp. e1006266, (2017) (PubMed).

Awate, De Benedetti: "TLK1B mediated phosphorylation of Rad9 regulates its nuclear/cytoplasmic localization and cell cycle checkpoint." in: BMC molecular biology, Vol. 17, pp. 3, (2016) (PubMed).

Chang, Chan, R McGhie, Udugama, Mayne, Collas, Mann, Wong: "CHK1-driven histone H3.3 serine 31 phosphorylation is important for chromatin maintenance and cell survival in human ALT cancer cells." in: Nucleic acids research, Vol. 43, Issue 5, pp. 2603-14, (2015) (PubMed).

Guo, Cui, Peng, Fang, Zuo, Deng, Wang, Wu, Chen, Deng: "Dietary NiCl₂ causes G₂/M cell cycle arrest in the broiler's kidney." in: Oncotarget, Vol. 6, Issue 34, pp. 35964-77, (2015) (PubMed).

Yun, Shi, Yang, Zhang, Wang, Zhou, Mu: "Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy." in: Scientific reports, Vol. 4, pp. 7548, (2015) (PubMed).

Synonyms and alternative names related to CHEK1

checkpoint kinase 1 (CHEK1), serine/threonine-protein kinase chk1 (ANI_1_2436074), serine/threonine-protein kinase chk1 (AOR_1_768154), serine/threonine-protein kinase Chk1 (PTRG_04183), CAMK/CAMKL/CHK1 protein kinase Chk1 (SJAG_01680), serine/threonine-protein kinase chk1 (PAAG_04978), serine/threonine-protein kinase chk1 (MCYG_03290), serine/threonine-protein kinase chk1 (VDBG_03742), checkpoint kinase 1 S homeolog (chek1.S), checkpoint kinase 1 (Chek1), checkpoint kinase 1 (chek1), An08g10320, AO090003000441, C85740, CHEK1, CHK1, chk1, Chk1, id:ibd2720, rad27, zgc:56093

Protein level used designations for CHEK1

  • CHK1 checkpoint homolog
  • Serine/threonine-protein kinase Chk1-like protein
  • serine/threonine-protein kinase Chk1
  • serine/threonine-protein kinase chk1
  • Checkpoint, S. pombe, homolog of, 1
  • Chk1-S
  • cell cycle checkpoint kinase
  • checkpoint kinase-1
  • Chk1 checkpoint kinase
  • xChk1
  • checkpoint kinase 1 homolog
  • rad27 homolog
  • 2720
  • integral membrane protein 1
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