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Human Polyclonal GATA1 Primary Antibody for IHC - ABIN966189
Zon, Tsai, Burgess, Matsudaira, Bruns, Orkin: The major human erythroid DNA-binding protein (GF-1): primary sequence and localization of the gene to the X chromosome. in Proceedings of the National Academy of Sciences of the United States of America 1990
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Human Monoclonal GATA1 Primary Antibody for ELISA, WB - ABIN969165
Blackford, Parmigiani, Kensler, Wolfgang, Jones, Zhang, Parsons, Lin, Leary, Eshleman, Goggins, Jaffee, Iacobuzio-Donahue, Maitra, Klein, Cameron, Olino, Schulick, Winter, Vogelstein, Velculescu, Kinzler, Hruban: Genetic mutations associated with cigarette smoking in pancreatic cancer. in Cancer research 2009
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Human Monoclonal GATA1 Primary Antibody for ICC, IHC - ABIN969166
Wierenga, Vellenga, Schuringa: Down-regulation of GATA1 uncouples STAT5-induced erythroid differentiation from stem/progenitor cell proliferation. in Blood 2010
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Human Monoclonal GATA1 Primary Antibody for ELISA, WB - ABIN966186
Yerges, Klei, Cauley, Roeder, Kammerer, Moffett, Ensrud, Nestlerode, Marshall, Hoffman, Lewis, Lang, Barrett-Connor, Ferrell, Orwoll, Zmuda: High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2009
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Human Polyclonal GATA1 Primary Antibody for IHC - ABIN966190
Kadri, Maouche-Chretien, Rooke, Orkin, Romeo, Mayeux, Leboulch, Chretien: Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation. in Molecular and cellular biology 2005
Cow (Bovine) Polyclonal GATA1 Primary Antibody for WB - ABIN2792607
de Vooght, van Wijk, van Solinge: GATA-1 binding sites in exon 1 direct erythroid-specific transcription of PPOX. in Gene 2008
Human Polyclonal GATA1 Primary Antibody for ELISA, WB - ABIN250863
Li, Godinho, Klusmann, Garriga-Canut, Yu, Orkin: Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. in Nature genetics 2005
Human Polyclonal GATA1 Primary Antibody for ICC, IF - ABIN4313642
Pontén, Jirström, Uhlen: The Human Protein Atlas--a tool for pathology. in The Journal of pathology 2008
Human Monoclonal GATA1 Primary Antibody for ELISA, ICC - ABIN4313641
Åström, Hahn-Strömberg, Zetterberg, Vedin, Merup, Palmblad: X-linked thrombocytopenia with thalassemia displays bone marrow reticulin fibrosis and enhanced angiogenesis: comparisons with primary myelofibrosis. in American journal of hematology 2015
Here, using zebrafish, murine, and human models, the authors show that erythropoietin (EPO (显示 EPO 抗体)) signaling, together with the GATA1 transcriptional target, AKAP10 (显示 AKAP10 抗体), regulates heme biosynthesis during erythropoiesis at the outer mitochondrial membrane.
expression of GATA1 effectively rescued maturation of Primary myelofibrosis megakaryocytes.
GATA1 is an essential downstream target of SENP1 (显示 SENP1 抗体) and that the differential expression and response of GATA1 and Bcl-xL (显示 BCL2L1 抗体) are a key mechanism underlying chronic mountain sickness pathology.
we herein show a long-distance regulatory region with GATA1 binding sites as being a strong enhancer for NBEAL2 (显示 NBEAL2 抗体) expression.
Single-nucleotide polymorphism in GATA1 gene is associated with non-Down syndrome transient proliferative megakaryoblastic disease.
These findings indicate that erythroid specific activator GATA-1 acts at CTCF (显示 CTCF 抗体) sites around the beta-globin (显示 HBB 抗体) locus to establish tissue-specific chromatin organization.
Results show that GATA1 recognizes a single GATA motif or a composite of adjacent GATA motifs and exerts its diversified bindings. These binding configurations serve as one of the critical determinants of specific transcriptional regulation.
Acquired and inherited GATA1 mutations contribute to Diamond-Blackfan anemia, acute megakaryoblastic leukemia, transient myeloproliferative disorder, and a group of related congenital dyserythropoietic anemias with thrombocytopenia.
Our results suggest that GATAl and miR (显示 MLXIP 抗体)-363 were involved in the regulation of hematopoiesis via the HIF-1alpha (显示 HIF1A 抗体) pathway in K562 cells under hypoxic condition.
analysis of GATA1 mutations in a cohort of Malaysian children with Down syndrome-associated myeloid disorder reveals distinctive genomic events
GATA1 may be a potential regulator of Six2 (显示 SIX2 抗体)-maintained population of nephron progenitor cells.
Gata1(low) mice are a bona fide model of MF, which recapitulates the hyperactivation of the TPO (显示 THPO 抗体)/MPL (显示 MPL 抗体)/JAK2 (显示 JAK2 抗体) axis observed in megakaryocytes from myelofibrotic patients.
the Gata-1 gene was a T3-directly regulated gene and that TRa1PV could impair erythropoiesis via repression of the Gata-1 gene and its regulated genes. These results provide new insights into how TRa1 (显示 HSP90B1 抗体) mutants acted to cause erythroid abnormalities in patients with mutations of the THRA (显示 THRA 抗体) gene.
Gain of function with GATA1 restores the common myeloid precursor differentiation into erythroblasts that was decreased by burn injury. There is a reciprocal relationship between myeloid-specific MafB (显示 MAFB 抗体) and erythroid-specific GATA1 in these cells. MafB (显示 MAFB 抗体) plays a role in dampening GATA1.
Gata1-KO(DC) DCs have reduced polysialic acid levels on their surface, which is a known determinant for the proper migration of DCs toward CCL21 (显示 CCL21 抗体).
removal of the the Gata1 methylation-determining region -mediated silencing machinery is the molecular basis of the initial activation of the Gata1 gene and erythropoiesis.
deletion of P-sel disrupted megakaryocyte/neutrophil interactions in spleen, reduced TGF-beta (显示 TGFB1 抗体) content, and corrected the hematopoietic stem cells distribution that in Gata1(low) mice, as in primary myelofibrosis patients, is abnormally expanded in spleen.
findings suggest that Gata1 & PU.1 transcription factors are only executing and reinforcing lineage choice once made. These results challenge the current prevailing model of early myeloid lineage choice
gata1 is required for early initiation of mpx (显示 MPO 抗体) expression in the intermediate cell mass, however later acts to repress the neutrophil fate
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein (显示 RBM24 抗体) Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 expression.
eaf1 (显示 EAF1 抗体) has a role in suppressing foxo3b expression to modulate transcriptional activity of gata1 and spi1 (显示 SPI1 抗体) in primitive hematopoiesis
The authors show that tif1gamma (显示 TRIM33 抗体) modulates the erythroid versus myeloid fate outcomes from HSCs by differentially controlling the levels of gata1 and pu.1.
this study provides evidence that Foggy/Spt5 (显示 SUPT5H 抗体) plays an important role in gata1 gene expression and erythropoiesis through its transcriptional activation domain.
These results showed that young thrombocytes have higher GATA1 promoter activity, while mature thrombocytes have more FLI1 (显示 FLI1 抗体) gene promoter transcription.
ability of Gata1 to self-associate critically contributes to the autoregulation of the gata1 gene
gata1 determines myelo-erythroid progenitor cell fate in zebrfish
Gata1 plays an integral role in directing myelo-erythroid lineage fate decisions during embryogenesis.
Two conserved miRNAs, miR (显示 MYLIP 抗体) 144 and miR (显示 MYLIP 抗体) 451, emerged as direct targets of the critical hematopoietic transcription factor GATA-1.
This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.
GATA-binding factor 1
, NF-E1 DNA-binding protein
, erythroid transcription factor
, erythroid transcription factor 1
, globin transcription factor 1
, nuclear factor, erythroid 1
, transcription factor GATA1
, GATA-binding protein 1
, GATA-binding protein 1 (globin transcription factor 1)
, GATA binding protein 1 (globin transcription factor 1)
, aspartyl/glutamyl-tRNA amidotransferase subunit A
, putative amidase
, glutamyl-tRNA amidotransferase subunit A
, hematopietic transcription factor GATA-1
, GATA 1 protein
, GATA binding protein 1
, GATA binding factor-1b
, GATA-binding factor 1-B
, transcription factor xGATA-1B
, GATA binding protein 1a
, vlad tepes
, LOW QUALITY PROTEIN: erythroid transcription factor-like
, erythroid-specific transcription factor eryf1