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抗Human SMAD2 抗体:
抗Mouse (Murine) SMAD2 抗体:
抗Rat (Rattus) SMAD2 抗体:
Human Monoclonal SMAD2 Primary Antibody for IF, IP - ABIN968106
Babu, Jeganathan, Baker, Wu, Kang-Decker, van Deursen: Rae1 is an essential mitotic checkpoint regulator that cooperates with Bub3 to prevent chromosome missegregation. in The Journal of cell biology 2003
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Human Monoclonal SMAD2 Primary Antibody for IF, IP - ABIN968105
Chen, Waters, Salmon, Murray: Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. in Science (New York, N.Y.) 1996
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN2801941
Liu, Pouponnot, Massagué: Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes. in Genes & development 1998
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Human Monoclonal SMAD2 Primary Antibody for ICC, FACS - ABIN969401
Wendt, Smith, Schiemann: p130Cas is required for mammary tumor growth and transforming growth factor-beta-mediated metastasis through regulation of Smad2/3 activity. in The Journal of biological chemistry 2009
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Human Monoclonal SMAD2 Primary Antibody for IF, IHC (p) - ABIN517619
Talvinen, Tuikkala, Nykänen, Nieminen, Anttinen, Nevalainen, Hurme, Kuopio, Kronqvist: Altered expression of p120catenin predicts poor outcome in invasive breast cancer. in Journal of cancer research and clinical oncology 2010
Human Polyclonal SMAD2 Primary Antibody for ICC, IF - ABIN4354659
Samanta, Gilkes, Chaturvedi, Xiang, Semenza: Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. in Proceedings of the National Academy of Sciences of the United States of America 2014
Chicken Polyclonal SMAD2 Primary Antibody for IHC (p), WB - ABIN4354661
Xu, Xue, Li, Bi, Cao: Marek's disease virus type 1 microRNA miR-M3 suppresses cisplatin-induced apoptosis by targeting Smad2 of the transforming growth factor beta signal pathway. in Journal of virology 2010
Human Polyclonal SMAD2 Primary Antibody for IHC, IHC (p) - ABIN4354665
Yamamura, Matsumura, Mandai, Huang, Oura, Baba, Hamanishi, Yamaguchi, Kang, Okamoto, Abiko, Mori, Murphy, Konishi: The activated transforming growth factor-beta signaling pathway in peritoneal metastases is a potential therapeutic target in ovarian cancer. in International journal of cancer 2011
Human Monoclonal SMAD2 Primary Antibody for FACS, IF - ABIN967045
Hannan, Jamshidi, Pera, Wolvetang: BMP-11 and myostatin support undifferentiated growth of human embryonic stem cells in feeder-free cultures. in Cloning and stem cells 2009
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Human Polyclonal SMAD2 Primary Antibody for WB - ABIN362416
Kim, Jong, Kim, Lee, Kim, Hong, Bang: Transforming growth factor-beta 1 induces apoptosis through Fas ligand-independent activation of the Fas death pathway in human gastric SNU-620 carcinoma cells. in Molecular biology of the cell 2004
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The non-Smad (显示 SMAD1 抗体) JNK (显示 MAPK8 抗体) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (显示 SMAD1 抗体) pathway, and this nuclear movement is associated with Smad (显示 SMAD1 抗体) signal transduction toward the nucleus.
The results of this study found that Bptf (显示 BPTF 抗体) and TGF-beta (显示 TGFB1 抗体)/Smad2 mediate nucleosome remodeling to regulate wnt8a (显示 WNT8A 抗体) expression and hence neural posteriorization.
Smad2 and Eomesodermin (显示 EOMES 抗体) a (Eomesa (显示 EOMES 抗体)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (显示 EOMES 抗体) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
a novel heterozygous missense mutation (c.833C>T, p.A278V) in the SMAD2 gene in a family with early onset aortic aneurysms
Data suggest that oncogenic Y-box binding protein 1 (YB-1 (显示 YBX1 抗体)) indirectly enhances transforming growth factor beta (TGFbeta (显示 TGFB1 抗体)) signaling cascades via Sma (显示 SMN1 抗体)/Mad related protein 2 (Smad2)phospho-activation and may represent a promising factor for future diagnosis and therapy of breast cancer.
Asiaticoside hindered the invasive growth of KFs (显示 GDF6 抗体) by inhibiting the GDF-9 (显示 GDF9 抗体)/MAPK (显示 MAPK1 抗体)/Smad (显示 SMAD1 抗体) pathway.
High Smad2 expression is associated with invasion and metastasis in pancreatic ductal adenocarcinoma.
Data indicate that miR (显示 MLXIP 抗体)-206 inhibits neuropilin-1 (NRP1 (显示 NRP1 抗体)) and SMAD2 gene expression by directly binding to their 3'-UTRs.
Results show that members of the Activin (显示 Actbeta 抗体) branch of the TGFbeta (显示 TGFB1 抗体) signaling pathway, namely Put and Smad2, are autonomously required for cell and tissue growth in the Drosophila larval salivary gland.
CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.
cells expressing mutant huntingtin (显示 HTT 抗体) have a dysregulated transcriptional response to epidermal growth factor (显示 EGF 抗体) stimulation
CRT (显示 SLC6A8 抗体) regulates TGF-beta1 (显示 TGFB1 抗体)-induced-EMT (显示 ITK 抗体) through modulating Smad (显示 SMAD1 抗体) signaling
P311 (显示 C5orf13 抗体) is a novel TGFbeta1 (显示 TGFB1 抗体)/Smad (显示 SMAD1 抗体) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
Grg4 (显示 TLE4 抗体) occupancy at the Xnr1 (显示 NODAL 抗体) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (显示 TLE4 抗体) from FoxH1 (显示 FOXH1 抗体) at the Xnr1 (显示 NODAL 抗体) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (显示 TCF3 抗体) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (显示 GDF11 抗体) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (显示 INHBA 抗体) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (显示 NANOG 抗体) and OCT4 (显示 POU5F1 抗体),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (显示 NANOG 抗体)/OCT4 (显示 POU5F1 抗体) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (显示 TGFB1 抗体) signalling that incorporates elements of previous models together with crosstalking between Smad1 (显示 SMAD1 抗体)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (显示 SMAD7 抗体).
NODAL/Activin (显示 Actbeta 抗体) signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2, acting via multiple mechanisms.
Blocking Smad2/3 signaling in pluripotent stem cells results in epigenetic changes that enhance the capacity for endoderm differentiation.
Smad2- and Smad3 (显示 SMAD3 抗体)-deficient bone marrow (BM) cells display reduced sensitivity to transforming growth factor-beta (TGFbeta (显示 TGFB1 抗体)) inhibition.
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (显示 LRRC32 抗体) is involved in up-regulation of Tgfb3 (显示 TGFB3 抗体) and is essential for embryogenesis of palate; Garp (显示 LRRC32 抗体) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (显示 LRRC32 抗体) = glycoprotein A repetitions predominant (显示 LRRC32 抗体) protein; Tgfb3 (显示 TGFB3 抗体) = transforming growth factor beta 3 (显示 TGFB3 抗体))
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (显示 TPM1 抗体), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (显示 TGFB1 抗体), Smad2, Smad3 (显示 SMAD3 抗体), Notch2 (显示 NOTCH2 抗体) and Notch3 (显示 NOTCH3 抗体) which, in turn, results in TGFbeta (显示 TGFB1 抗体) and Notch (显示 NOTCH1 抗体) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (显示 SMAD7 抗体) expression was increased after treatment with osthole.
These findings implicate TGF-beta (显示 TGFB1 抗体)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2