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SMAD2 抗体 (pSer467)

SMAD2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6256347
发货至: 中国
  • 抗原 See all SMAD2 抗体
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    抗原表位
    • 47
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    • 9
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    pSer467
    适用
    • 235
    • 149
    • 116
    • 12
    • 12
    • 9
    • 9
    • 8
    • 7
    • 7
    • 7
    • 6
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    人, 小鼠, 大鼠
    宿主
    • 238
    • 10
    克隆类型
    • 212
    • 36
    多克隆
    标记
    • 126
    • 18
    • 12
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    • 8
    • 8
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    • 8
    • 7
    • 7
    • 5
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    This SMAD2 antibody is un-conjugated
    应用范围
    • 210
    • 100
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    • 53
    • 52
    • 43
    • 41
    • 38
    • 17
    • 14
    • 10
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    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    特异性
    Phospho-Smad2 (Ser467) Antibody detects endogenous levels of Smad2 only when phosphorylated at Serine 467.
    预测反应
    Pig,Zebrafish,Bovine,Sheep,Rabbit,Dog,Xenopus
    纯化方法
    The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho- and non-phospho-peptide affinity columns.
    免疫原
    A synthesized peptide derived from human Smad2 around the phosphorylation site of Ser467.
    亚型
    IgG
    Top Product
    Discover our top product SMAD2 Primary Antibody
  • 应用备注
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20 °C. Stable for 12 months from date of receipt.
    有效期
    12 months
  • 抗原
    SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))
    别名
    SMAD2 (SMAD2 产品)
    别名
    JV18 antibody, JV18-1 antibody, MADH2 antibody, MADR2 antibody, hMAD-2 antibody, hSMAD2 antibody, jv18 antibody, Xmad2 antibody, madh2 antibody, madr2 antibody, XSmad2 antibody, hmad-2 antibody, hsmad2 antibody, jv18-1 antibody, smad-2 antibody, fj43c06 antibody, wu:fj43c06 antibody, 7120426M23Rik antibody, Madh2 antibody, Madr2 antibody, Smad-2 antibody, mMad2 antibody, MAD homolog 2 antibody, Mothers against DPP homolog 2 antibody, SMAD 2 antibody, Smad2 antibody, SMAD family member 2 antibody, SMAD family member 2-Z antibody, SMAD family member 2 S homeolog antibody, SMAD2 antibody, SMAD2Z antibody, smad2 antibody, smad2.S antibody, Smad2 antibody
    背景

    Description: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

    Gene: SMAD2

    分子量
    58kDa
    基因ID
    4087
    UniProt
    Q15796
    途径
    Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus
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