anti-CDKN1B (CDKN1B) 抗体产品概述

Human Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. FLT3 (显示 FLT3 抗体) and FLT3 (显示 FLT3 抗体)-ITD can directly bind and selectively phosphorylate p27kip1 on tyrosine residue 88 in acute myeloid leukemia (显示 BCL11A 抗体). Inhibition of FLT3 (显示 FLT3 抗体)-ITD in cell lines strongly reduced p27 (显示 PAK2 抗体) tyrosine 88 phosphorylation and resulted in increased p27 (显示 PAK2 抗体) levels and cell cycle arrest

2. Our results suggest that oxidised photoreceptor outer segments -induced retinal pigment epithelial cell cytokinesis failure is, at least in part, due to the upregulation of p27kip1 through activating the PKC (显示 PRRT2 抗体), particularly PKCzeta (显示 PRKCZ 抗体) pathway

3. p27Kip1-838C>A; rs36228499 is functional in human venous smooth muscle cells (SMCs) and in adventitial cells. The AA genotype is associated with stronger expression of the p27 (显示 PAK2 抗体) gene and p27 (显示 PAK2 抗体) protein. Only the adventitial cells, and not the SMCs, are responsive to the inhibitory effects of the protective AA genotype in cell growth.

4. Overview of CDKN1B mutations in MEN4 (review)

5. Expression of CIP/KIP (显示 CIB1 抗体) proteins was found abundantly within the proliferative hair matrix, concomitant with a role in cell cycle checkpoint control. p21(CIP1 (显示 CDKN1A 抗体)), p27(KIP1) and cyclin E (显示 CCNE1 抗体) persisted within post-mitotic keratinocytes of the pre-cortex, whereas p57(KIP2 (显示 CDKN1C 抗体)) protein decreased but became nuclear.

6. Taken together, these data clearly show that FKBP3 (显示 FKBP3 抗体)/Sp1 (显示 PSG1 抗体)/HDAC2 (显示 HDAC2 抗体)/p27 (显示 PAK2 抗体) control cell proliferation during non-small cell lung cancer development.

7. Sumoylation of K73 (显示 KRT73 抗体) site of cyclin-dependent kinase inhibitor 1B (p27kip1) is critical to the nuclear-cytoplasmic translocation of p27kip1, which is mediated by RAN binding protein 2 (显示 RANBP2 抗体) and CRM1 (显示 XPO1 抗体) protein. Sumoylation of p27kip1 promotes the proliferation of cholangiocarcinoma QBC939 cells

8. loss of CDKN1B increased the prevalence of cell cycle regulator defects in immature T-ALL, usually only ascribed to CDKN2A/B deletions, and that CDKN1B deletions frequently coincide with expression of MEF2C (显示 MEF2C 抗体), considered as one of the driving oncogenes in immature early T-cell precursor (ETP) ALL

9. This study reveals a molecular pathway involving lncRNA GAS5/E2F1 (显示 E2F1 抗体)/P27(Kip1) which regulates cell proliferation and could be a potential therapeutic target in prostate cancer.

10. miR (显示 MLXIP 抗体)-155-5p promotes fibroblast cell proliferation and inhibits FOXO (显示 FOXO3 抗体) signaling pathway by negative modulation of both FOXO3 (显示 FOXO3 抗体) and CDKN1B in vulvar lichen sclerosis

Zebrafish Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

Cow (Bovine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. p27Kip1 inhibition has an effect on proliferation of bovine corneal endothelial cells by RNA interferenc

Pig (Porcine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. FoxO1a (显示 FOXO1 抗体) can regulate p27kip nuclear localization

2. the activation of Rac1 due to the cell-cell contact plays a critical role in the transcriptional up-regulation of p27Kip1 in vascular endothelial cells.

Mouse (Murine) Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B) interaction partners

1. Findings demonstrate functional interplay between a transcriptional regulator and p27(kip1) to mediate neuroprogenitor cell cycle exit, as well as to promote radial migration through a molecular mechanism consistent with suppression of RhoA (显示 RHOA 抗体) signaling.

2. Specifically, the proteins p18INK4C (显示 CDKN2C 抗体), p21CIP1 (显示 CDKN1A 抗体) and p27KIP1 seem to play an outstanding role in the maintenance of the differentiated state of adipocytes.

3. Data show that both bone marrow-derived and gastric epithelial cells contribute to the increased gastric cancer susceptibility of p27-deficient Helicobacter pylori (H. pylori) -infected mice.

4. Our results revealed that CKS1 (显示 CKS1B 抗体) is involved in normal glutamatergic synapse development and dendritic spine maturation in adult hippocampus through modulating p27 stability.

5. p27kip1 is involved in the decisive step around cell-cycle exit and plays an important role in activity-regulated and functionally relevant adult hippocampal neurogenesis.

6. p27(Kip1)-target genes are involved in cell adhesion and cell signaling in mouse embryonic fibroblasts.

7. This study demonstrates that LMP2A uses the role of MYC (显示 MYC 抗体) in the cell cycle, particularly in the p27(kip1) degradation process, to accelerate lymphomagenesis in vivo.

8. Study reports that p27 normally exerts a negative feedback on p21 (显示 D4S234E 抗体) expression: p27 directly represses the expression of the transcription factor Pitx2 (显示 PITX2 抗体) which in turn maintains decreased p21 (显示 D4S234E 抗体) levels. Consequently, in cells lacking p27, de-repression of Pitx2 (显示 PITX2 抗体) causes the up-regulation of p21 (显示 D4S234E 抗体) showing a new mechanism by which p27 regulates cell cycle progression by transcriptionally regulating the expression of Pitx2 (显示 PITX2 抗体) and p21 (显示 D4S234E 抗体).

9. Fbxo7 (显示 FBXO7 抗体)-deficient immature thymocytes failed to undergo expansion in the thymus due to a lack of Cdk6 (显示 CDK6 抗体) activity, while mature T cells showed enhanced proliferative capacity upon T-cell receptor engagement due to reduced p27 levels. These studies reveal differential cell cycle regulation by Fbxo7 (显示 FBXO7 抗体) at different stages in T-cell development.

10. systems-level control of cell cycle arrest by pRB (显示 PGR 抗体)-E2F (显示 E2F1 抗体) and p27-CDK (显示 CDK4 抗体) regulation, is reported.