(CDK5 Regulatory Subunit Associated Protein 3 (CDK5RAP3))
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein, which may be a substrate of neuronal CDC2-like kinase, has also been found in vascular endothelial cells, where it mediates cell proliferation. [provided by RefSeq, Jul 2008].
Shiwaku, Yoshimura, Tamura, Sone, Ogishima, Watase, Tagawa, Okazawa: "Suppression of the novel ER protein Maxer by mutant ataxin-1 in Bergman glia contributes to non-cell-autonomous toxicity." in: The EMBO journal, Vol. 29, Issue 14, pp. 2446-60, (2010) (PubMed).