CD46 抗体
(CD46)
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010].
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Latest Publications for our CD46 抗体
: "The Role of Taste Receptor mTAS1R3 in Chemical Communication of Gametes." in: International journal of molecular sciences, Vol. 21, Issue 7, (2020) (PubMed).
: "An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor." in: Cell, Vol. 174, Issue 5, pp. 1158-1171.e19, (2019) (PubMed).
: "Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus." in: European journal of immunology, Vol. 47, Issue 7, pp. 1200-1210, (2017) (PubMed).
: "Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic." in: Molecular therapy. Methods & clinical development, Vol. 5, pp. 16013, (2016) (PubMed).
: "Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors." in: Journal of virology, Vol. 89, Issue 3, pp. 1512-22, (2015) (PubMed).
: "Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy." in: Molecular immunology, Vol. 65, Issue 2, pp. 302-9, (2015) (PubMed).
: "A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b." in: Journal of virology, Vol. 89, Issue 2, pp. 989-98, (2015) (PubMed).
: "Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?" in: Journal of neuroimmunology, Vol. 276, Issue 1-2, pp. 172-4, (2014) (PubMed).
: "Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5." in: Virology journal, Vol. 9, pp. 296, (2013) (PubMed).
: "Immunohistochemical localization of complement regulatory proteins in the human retina." in: Histology and histopathology, Vol. 27, Issue 3, pp. 357-64, (2012) (PubMed).
: "An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor." in: Cell, Vol. 174, Issue 5, pp. 1158-1171.e19, (2019) (PubMed).
: "Dysregulated CD46 shedding interferes with Th1-contraction in systemic lupus erythematosus." in: European journal of immunology, Vol. 47, Issue 7, pp. 1200-1210, (2017) (PubMed).
: "Preclinical safety, pharmacokinetics, pharmacodynamics, and biodistribution studies with Ad35K++ protein: a novel rituximab cotherapeutic." in: Molecular therapy. Methods & clinical development, Vol. 5, pp. 16013, (2016) (PubMed).
: "Construction and evaluation of novel rhesus monkey adenovirus vaccine vectors." in: Journal of virology, Vol. 89, Issue 3, pp. 1512-22, (2015) (PubMed).
: "Expression of membrane complement regulators, CD46, CD55 and CD59, in mesothelial cells of patients on peritoneal dialysis therapy." in: Molecular immunology, Vol. 65, Issue 2, pp. 302-9, (2015) (PubMed).
: "A novel factor I activity in Nipah virus inhibits human complement pathways through cleavage of C3b." in: Journal of virology, Vol. 89, Issue 2, pp. 989-98, (2015) (PubMed).
: "Complement regulatory proteins (CD46, 55 and 59) expressed on Schwann cells: immune targets in demyelinating neuropathies?" in: Journal of neuroimmunology, Vol. 276, Issue 1-2, pp. 172-4, (2014) (PubMed).
: "Intracardiac injection of a capsid-modified Ad5/35 results in decreased heart toxicity when compared to standard Ad5." in: Virology journal, Vol. 9, pp. 296, (2013) (PubMed).
: "Immunohistochemical localization of complement regulatory proteins in the human retina." in: Histology and histopathology, Vol. 27, Issue 3, pp. 357-64, (2012) (PubMed).
Aliases for CD46 抗体
CD46 molecule (CD46) 抗体CD46 antigen, complement regulatory protein (Cd46) 抗体
CD46 molecule (Cd46) 抗体
CD46 molecule, complement regulatory protein (CD46) 抗体
membrane cofactor protein-like (LOC100341359) 抗体
membrane cofactor protein-like (LOC103789310) 抗体
AHUS2 抗体
CD46 抗体
MCP 抗体
Mcp 抗体
MIC10 抗体
TLX 抗体
TRA2.10 抗体
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