Caspase 1 产品
(Caspase 1 (CASP1))
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This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012].
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Featured Caspase 1 Categories
Caspase 1 抗体
High quality antibodies with extensive validation data.
Caspase 1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
Caspase 1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Caspase 1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7433831
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (7)
Cat. No.
ABIN7438055
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (8)
Cat. No.
ABIN7437506
Quantity
100 μL
Datasheet
Datasheet
Recommended Caspase 1 ELISA试剂盒
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Reactivity
Analytical Method
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Cat. No.
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Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (4)
- (5)
Cat. No.
ABIN6574284
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN6954410
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6965449
Quantity
96 tests
Datasheet
Datasheet
Recommended Caspase 1 蛋白
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Reactivity
Source
Validations
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Datasheet
Reactivity
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Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122160
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122161
Quantity
50 μg
Datasheet
Datasheet
Reactivity
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Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1348088
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our Caspase 1 Products
: "Impaired SERPIN-Protease Balance in the Peripheral Lungs of Stable COPD Patients." in: International journal of molecular sciences, Vol. 26, Issue 7, (2025) (PubMed).: "XIST Inhibition Attenuates Calcium Oxalate Nephrocalcinosis-Induced Renal Inflammation and Oxidative Injury via the miR-223/NLRP3 Pathway." in: Oxidative medicine and cellular longevity, Vol. 2021, pp. 1676152, (2022) (PubMed).
: "Efficient and Consistent Orthotopic Osteosarcoma Model by Cell Sheet Transplantation in the Nude Mice for Drug Testing." in: Frontiers in bioengineering and biotechnology, Vol. 9, pp. 690409, (2021) (PubMed).
: "Enhanced Autolysosomal Function Ameliorates the Inflammatory Response Mediated by the NLRP3 Inflammasome in Alzheimer's Disease." in: Frontiers in aging neuroscience, Vol. 13, pp. 629891, (2021) (PubMed).
: "HMGB1 participates in LPS‑induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF‑κB signaling pathways." in: International journal of molecular medicine, Vol. 45, Issue 1, pp. 61-80, (2020) (PubMed).
: "Serum Caspase-1 levels in women with polycystic ovary syndrome." in: Taiwanese journal of obstetrics & gynecology, Vol. 59, Issue 2, pp. 207-210, (2020) (PubMed).
: "Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways." in: Chemico-biological interactions, Vol. 297, pp. 25-33, (2019) (PubMed).
: "Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. ..." in: Immunity, Vol. 49, Issue 1, pp. 42-55.e6, (2019) (PubMed).
: "Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome." in: Mucosal immunology, Vol. 12, Issue 4, pp. 862-873, (2019) (PubMed).
: "Whole Body Vibration Therapy after Ischemia Reduces Brain Damage in Reproductively Senescent Female Rats." in: International journal of molecular sciences, Vol. 19, Issue 9, (2019) (PubMed).
Synonyms and alternative names related to Caspase 1
caspase 1 (CASP1), caspase 1 (Casp1), caspase 1, apoptosis-related cysteine peptidase (CASP1), caspase 4, apoptosis-related cysteine peptidase (CASP4), Death caspase-1 (Dcp-1), caspase-1 (Caspase1), caspase (LOC5564196), caspase recruitment domain-containing protein 16 (LOC451519), caspase-1 (CASP1), caspase 4 (CASP4), CASP1, ccp1, CG5370, DCP-1, dcp-1, DCP1, Dcp1, dcp1, Dmel\\CG5370, ICE, Ice, IL1BC, Il1bc, l(2)01862, l(2)02132, P45Protein level used designations for Caspase 1
- CASP1 nirs variant 1
- IL-1 beta-converting enzyme
- IL1B-convertase
- caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
- caspase-1
- interleukin 1, beta, convertase
- interleukin 1-B converting enzyme
- CASP-1
- IL-1B converting enzyme
- IL-1BC
- interleukin 1 beta-converting enzyme
- interleukin-1 beta convertase
- interleukin-1 beta-converting enzyme
- p45
- Interleukin 1beta converting enzyme
- caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
- ICE
- interleukin-1 beta converting enzyme
- caspase-1/caspase-4 hybrid
- CG5370-PA
- Dcp-1-PA
- caspase
- caspase 1
- death caspase-1
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