CARD8 抗体
(Caspase Recruitment Domain Family, Member 8 (CARD8))
The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010].
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Latest Publications for our CARD8 抗体
: "Loss-of-function CARD8 mutation causes NLRP3 inflammasome activation and Crohn's disease." in: The Journal of clinical investigation, Vol. 128, Issue 5, pp. 1793-1806, (2018) (PubMed).: "CARD-8 protein, a new CARD family member that regulates caspase-1 activation and apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13952-8, (2002) (PubMed).
: "TUCAN/CARDINAL and DRAL participate in a common pathway for modulation of NF-kappaB activation." in: FEBS letters, Vol. 521, Issue 1-3, pp. 165-9, (2002) (PubMed).
: "TUCAN, an antiapoptotic caspase-associated recruitment domain family protein overexpressed in cancer." in: The Journal of biological chemistry, Vol. 276, Issue 34, pp. 32220-9, (2001) (PubMed).
: "DRAL is a p53-responsive gene whose four and a half LIM domain protein product induces apoptosis." in: The Journal of cell biology, Vol. 151, Issue 3, pp. 495-506, (2000) (PubMed).
Aliases for CARD8 抗体
caspase recruitment domain family, member 8 (CARD8) 抗体caspase recruitment domain-containing protein 8 (LOC718594) 抗体
caspase recruitment domain family member 8 (CARD8) 抗体
CARD8 抗体
CARDINAL 抗体
DACAR 抗体
DAKAR 抗体
NDPP 抗体
NDPP1 抗体
TUCAN 抗体
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