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CACNB4 产品

(Calcium Channel, Voltage-Dependent, beta 4 Subunit (CACNB4))

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This gene encodes a member of the beta subunit family of voltage-dependent calcium channel complex proteins. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein encoded by this locus plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].

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Featured CACNB4 Categories

CACNB4 抗体

High quality antibodies with extensive validation data.

CACNB4 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended CACNB4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse
Application WB, IF, ICC, IHC (p)
Validations
  • (4)
Cat. No. ABIN2854649
Quantity 100 μL
Datasheet Datasheet
Reactivity Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application WB
Validations
  • (4)
Cat. No. ABIN2774681
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
Cat. No. ABIN7175600
Quantity 100 μg
Datasheet Datasheet

Recommended CACNB4 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6213229
Quantity 96 tests
Datasheet Datasheet

Recommended CACNB4 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1347838
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1347836
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3090330
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our CACNB4 Products

Scamps, Sangari, Bowerman, Rousset, Bellis, Cens, Charnet: "Nerve injury induces a Gem-GTPase-dependent downregulation of P/Q-type Ca2+ channels contributing to neurite plasticity in dorsal root ganglion neurons." in: Pflügers Archiv : European journal of physiology, Vol. 467, Issue 2, pp. 351-66, (2015) (PubMed).

Etemad, Obermair, Bindreither, Benedetti, Stanika, Di Biase, Burtscher, Koschak, Kofler, Geley, Wille, Lusser, Flockerzi, Flucher: "Differential neuronal targeting of a new and two known calcium channel ?4 subunit splice variants correlates with their regulation of gene expression." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 4, pp. 1446-61, (2014) (PubMed).

Liu, Bickford, Held, Nyitrai, Südhof, Kaeser: "The active zone protein family ELKS supports Ca2+ influx at nerve terminals of inhibitory hippocampal neurons." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 37, pp. 12289-303, (2014) (PubMed).

Daschil, Obermair, Flucher, Stefanova, Hutter-Paier, Windisch, Humpel, Marksteiner: "CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-? plaques in an Alzheimer's disease mouse model." in: Journal of Alzheimer's disease : JAD, Vol. 37, Issue 2, pp. 439-51, (2013) (PubMed).

Li, Cao, Chen, Han, Lopez-Berestein, Sood, Pan: "Up-regulation of Cav?3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain." in: The Journal of biological chemistry, Vol. 287, Issue 8, pp. 6002-13, (2012) (PubMed).

Ferrándiz-Huertas, Gil-Mínguez, Luján: "Regional expression and subcellular localization of the voltage-gated calcium channel ? subunits in the developing mouse brain." in: Journal of neurochemistry, Vol. 122, Issue 6, pp. 1095-107, (2012) (PubMed).

Kaeser, Deng, Wang, Dulubova, Liu, Rizo, Südhof: "RIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction." in: Cell, Vol. 144, Issue 2, pp. 282-95, (2011) (PubMed).

Abiria, Colbran: "CaMKII associates with CaV1.2 L-type calcium channels via selected beta subunits to enhance regulatory phosphorylation." in: Journal of neurochemistry, Vol. 112, Issue 1, pp. 150-61, (2010) (PubMed).

Obermair, Schlick, Di Biase, Subramanyam, Gebhart, Baumgartner, Flucher: "Reciprocal interactions regulate targeting of calcium channel beta subunits and membrane expression of alpha1 subunits in cultured hippocampal neurons." in: The Journal of biological chemistry, Vol. 285, Issue 8, pp. 5776-91, (2010) (PubMed).

Ortiz-Miranda, Dayanithi, Velázquez-Marrero, Custer, Treistman, Lemos: "Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals." in: Journal of cellular physiology, Vol. 225, Issue 1, pp. 276-88, (2010) (PubMed).

Synonyms and alternative names related to CACNB4

calcium voltage-gated channel auxiliary subunit beta 4 (CACNB4), calcium channel, voltage-dependent, beta 4 subunit (Cacnb4), calcium voltage-gated channel auxiliary subunit beta 4 (Cacnb4), calcium channel, voltage-dependent, beta 4 subunit (cacnb4.1), calcium channel, voltage-dependent, beta 4 subunit (cacnb4), calcium channel, voltage-dependent, beta 4a subunit (cacnb4a), 3110038O15Rik, CAB4, CACNB4, cacnb4.2, CACNLB4, Cchb4, EA5, EIG9, EJM, EJM4, EJM6, lethargic, lh

Protein level used designations for CACNB4

  • calcium channel voltage-dependent subunit beta 4
  • dihydropyridine-sensitive L-type, calcium channel beta-4 subunit
  • voltage-dependent L-type calcium channel subunit beta-4
  • CAB4
  • calcium channel beta 4 subunit
  • voltage-dependent calcium channel beta 4 subunit
  • calcium channel, voltage-dependent, beta 4 subunit
  • voltage-gated calcium channel beta 4.1 subunit
  • voltage-dependent L-type calcium channel subunit beta-4-like
  • CAB4a
  • voltage-dependent calcium channel beta 4a subunit
  • voltage-gated calcium channel beta-4.2
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