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Cadherin 4 产品

(Cadherin 4 (CDH4))
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium-dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Based on studies in chicken and mouse, this cadherin is thought to play an important role during brain segmentation and neuronal outgrowth. In addition, a role in kidney and muscle development is indicated. Of particular interest are studies showing stable cis-heterodimers of cadherins 2 and 4 in cotransfected cell lines. Previously thought to interact in an exclusively homophilic manner, this is the first evidence of cadherin heterodimerization. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011].

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Featured Cadherin 4 Categories

Cadherin 4 抗体

High quality antibodies with extensive validation data.

Cadherin 4 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

Cadherin 4 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Cadherin 4 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IF, FACS, IHC (p)
Validations
  • (1)
  • (5)
Cat. No. ABIN388148
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application WB, IF, FACS, IHC (p), EIA
Validations
  • (4)
Cat. No. ABIN356865
Quantity 0.4 mL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (2)
Cat. No. ABIN560277
Quantity 100 μg
Datasheet Datasheet

Recommended Cadherin 4 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730333
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN4882287
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Semi-Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6385128
Quantity 96 tests
Datasheet Datasheet

Recommended Cadherin 4 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1348916
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3133940
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3090339
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Cadherin 4 Products

Mills, Globa, Liu, Cowan, Mobasser, Phillips, Borgland, Bamji: "Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning." in: Nature neuroscience, Vol. 20, Issue 4, pp. 540-549, (2017) (PubMed).

Cremaschi, Oliverio, Leva, Bione, Carriero, Mazzucco, Palamidessi, Scita, Biamonti, Montecucco: "Chronic Replication Problems Impact Cell Morphology and Adhesion of DNA Ligase I Defective Cells." in: PLoS ONE, Vol. 10, Issue 7, pp. e0130561, (2015) (PubMed).

Aschauer, Gruber, Pfaller, Limonciel, Athersuch, Cavill, Khan, Gstraunthaler, Grillari, Grillari, Hewitt, Leonard, Wilmes, Jennings: "Delineation of the key aspects in the regulation of epithelial monolayer formation." in: Molecular and cellular biology, Vol. 33, Issue 13, pp. 2535-50, (2013) (PubMed).

Li, Takai, Yuge, Furukawa, Tsuno, Tsukamoto, Kong, Moriyama, Narahara: "Novel target genes responsive to the anti-growth activity of triptolide in endometrial and ovarian cancer cells." in: Cancer letters, Vol. 297, Issue 2, pp. 198-206, (2010) (PubMed).

Johnson, Theisen, Johnson, Wheelock: "R-cadherin influences cell motility via Rho family GTPases." in: The Journal of biological chemistry, Vol. 279, Issue 30, pp. 31041-9, (2004) (PubMed).

Miotto, Sabbioni, Veronese, Calin, Gullini, Liboni, Gramantieri, Bolondi, Ferrazzi, Gafà, Lanza, Negrini: "Frequent aberrant methylation of the CDH4 gene promoter in human colorectal and gastric cancer." in: Cancer research, Vol. 64, Issue 22, pp. 8156-9, (2004) (PubMed).

Kitagawa, Natori, Murase, Hirano, Taketani, Suzuki: "Mutation analysis of cadherin-4 reveals amino acid residues of EC1 important for the structure and function." in: Biochemical and biophysical research communications, Vol. 271, Issue 2, pp. 358-63, (2000) (PubMed).

Tanihara, Sano, Heimark, St John, Suzuki: "Cloning of five human cadherins clarifies characteristic features of cadherin extracellular domain and provides further evidence for two structurally different types of cadherin." in: Cell adhesion and communication, Vol. 2, Issue 1, pp. 15-26, (1995) (PubMed).

Hutton, Christofori, Chi, Edman, Guest, Hanahan, Kelly: "Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue." in: Molecular endocrinology (Baltimore, Md.), Vol. 7, Issue 9, pp. 1151-60, (1994) (PubMed).

Matsunami, Miyatani, Inoue, Copeland, Gilbert, Jenkins, Takeichi: "Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene." in: Journal of cell science, Vol. 106 ( Pt 1), Issue 6, pp. 401-9, (1994) (PubMed).

Synonyms and alternative names related to Cadherin 4

cadherin 4 (cdh4), cadherin 4 (Cdh4), cadherin 4, type 1, R-cadherin (retinal) (cdh4), cadherin 4 (CDH4), Cadherin-4 (cdh-4), AW120700, cad4, CAD4, cadherin-4, Cdh4l, R-Cadh, R-cadherin, rcad, Rcad, RCAD, zgc:136316

Protein level used designations for Cadherin 4

  • cadherin 4, type 1, R-cadherin (retinal)
  • R-CAD
  • cadherin-4
  • retina cadherin
  • retinal cadherin
  • R-cadherin
  • cadherin 4 type 1 R-cadherin (retinal)
  • cadherin 4, type 1, preproprotein
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