Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component (By similarity).
custom-made
BABAM1
宿主: 小鼠
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
custom-made
BABAM1
宿主: 人
宿主: Cell-free protein synthesis (CFPS)
Recombinant
approximately 70-80 % as determined by SDS PAGE, Western Blot and analytical SEC (HPLC).
ELISA, WB, SDS
BRISC and BRCA1 A complex member 1 (babam1) 蛋白 BRISC and BRCA1 A complex member 1 (BABAM1) 蛋白 BRISC and BRCA1 A complex member 1 L homeolog (babam1.L) 蛋白 BRISC and BRCA1 A complex member 1 (Babam1) 蛋白 5430437P03Rik 蛋白 C7H19orf62 蛋白 c19orf62 蛋白 C19orf62 蛋白 merit40 蛋白 MERIT40 蛋白 Merit40 蛋白 nba1 蛋白 NBA1 蛋白 zgc:100909 蛋白