BRCC3 蛋白
(BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011].
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9 results
BRCC3
宿主: 人
宿主: 大肠杆菌（E. Coli）
Recombinant
> 95 %
SDS, WB, Imm, PC
Aliases for BRCC3 蛋白
BRCA1/BRCA2-containing complex subunit 3 (BRCC3) 蛋白DEP domain containing 1B (depdc1b) 蛋白
BRCA1/BRCA2-containing complex subunit 3 (brcc3) 蛋白
BRCA1/BRCA2-containing complex, subunit 3 (Brcc3) 蛋白
BRCA1/BRCA2-containing complex subunit 3 L homeolog (brcc3.L) 蛋白
BRCC3 蛋白
brcc3 蛋白
BRCC36 蛋白
brcc36 蛋白
C6.1A 蛋白
CXorf53 蛋白
xtp1 蛋白
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