Branched Chain Amino-Acid Transaminase 1, Cytosolic 产品
(Branched Chain Amino-Acid Transaminase 1, Cytosolic (BCAT1))
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This gene encodes the cytosolic form of the enzyme branched-chain amino acid transaminase. This enzyme catalyzes the reversible transamination of branched-chain alpha-keto acids to branched-chain L-amino acids essential for cell growth. Two different clinical disorders have been attributed to a defect of branched-chain amino acid transamination: hypervalinemia and hyperleucine-isoleucinemia. As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2010].
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Featured Branched Chain Amino-Acid Transaminase 1, Cytosolic Categories
Branched Chain Amino-Acid Transaminase 1, Cytosolic 抗体
High quality antibodies with extensive validation data.
Branched Chain Amino-Acid Transaminase 1, Cytosolic 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended Branched Chain Amino-Acid Transaminase 1, Cytosolic 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Rat
Application
WB, IHC, IP, ICC
Validations
- (6)
Cat. No.
ABIN7445063
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7445177
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (4)
Cat. No.
ABIN7445060
Quantity
100 μL
Datasheet
Datasheet
Recommended Branched Chain Amino-Acid Transaminase 1, Cytosolic ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6227409
Quantity
96 tests
Datasheet
Datasheet
Recommended Branched Chain Amino-Acid Transaminase 1, Cytosolic 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7562994
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
HEK-293 Cells
Validations
- (3)
Cat. No.
ABIN7552661
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7122027
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our Branched Chain Amino-Acid Transaminase 1, Cytosolic Products
: "Defect of branched-chain amino acid metabolism promotes the development of Alzheimer's disease by targeting the mTOR signaling." in: Bioscience reports, Vol. 38, Issue 4, (2018) (PubMed).: "BCAT1 is a New MR Imaging-related Biomarker for Prognosis Prediction in IDH1-wildtype Glioblastoma Patients." in: Scientific reports, Vol. 7, Issue 1, pp. 17740, (2017) (PubMed).
: "Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia." in: Nature, Vol. 545, Issue 7655, pp. 500-504, (2017) (PubMed).
: "Smed-betacatenin-1 is required for anteroposterior blastema polarity in planarian regeneration." in: Science (New York, N.Y.), Vol. 319, Issue 5861, pp. 327-30, (2008) (PubMed).
: "Up-regulation of Akt3 in estrogen receptor-deficient breast cancers and androgen-independent prostate cancer lines." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 21528-32, (1999) (PubMed).
: "Involvement of Myc targets in c-myc and N-myc induced human tumors." in: Oncogene, Vol. 17, Issue 2, pp. 165-71, (1998) (PubMed).
: "High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity." in: The Journal of biological chemistry, Vol. 272, Issue 13, pp. 8474-81, (1997) (PubMed).
: "ECA39 is regulated by c-Myc in human and by a Jun/Fos homolog, Gcn4, in yeast." in: Oncogene, Vol. 13, Issue 9, pp. 1859-66, (1997) (PubMed).
: "Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B." in: Nature, Vol. 378, Issue 6559, pp. 785-9, (1996) (PubMed).
: "Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases." in: The Journal of biological chemistry, Vol. 271, Issue 34, pp. 20242-5, (1996) (PubMed).
Synonyms and alternative names related to Branched Chain Amino-Acid Transaminase 1, Cytosolic
branched chain amino acid transaminase 1 (BCAT1), branched chain aminotransferase 1, cytosolic (Bcat1), branched chain amino acid transaminase 1 (Bcat1), branched chain amino-acid transaminase 1, cytosolic (bcat1), branched chain amino-acid transaminase 1, cytosolic L homeolog (bcat1.L), branched chain aminotransferase 1, cytosolic (bcat1), branched chain amino acid transaminase 1 (bcat1), branched-chain amino acid transaminase 1 (BCAT-1), ATBCAT-1, BCATC, BCATc, Bcatc, BCT1, branched-chain amino acid transaminase 1, ECA39, Eca39, fj66g02, MECA39, PNAS121, PP18, T27I1.8, T27I1_8, wu:fj66g02, zgc:73157Protein level used designations for Branched Chain Amino-Acid Transaminase 1, Cytosolic
- branched chain aminotransferase 1, cytosolic
- branched-chain-amino-acid aminotransferase, cytosolic
- placental protein 18
- BCAT(c)
- cytosolic branched-chain amino acid aminotransferase
- branched chain amino-acid transaminase 1, cytosolic
- branched-chain-amino-acid aminotransferase, cytosolic-like
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