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Human SERPINB2 ELISA Kit for Sandwich ELISA - ABIN417368
Koopmans, Brouwer, Geldhoff, Seron, Houben, van der Ende, van de Beek: Cerebrospinal fluid inflammatory markers in patients with Listeria monocytogenes meningitis. in BBA clinical 2015
The current study revealed a significant increase level of TAFI and PAI-1, coupled with a decrease in PAI-2 in women with severe preeclampsia in comparison with the control group.
PAI-2 likely plays a key role in cardiovascular disease through multiple pathophysiologic processes including racial dependency, platelet clot (显示 TXNDC17 ELISA试剂盒) initiation and propagation, oxidative stress, inflammation effects on HDL (显示 HSD11B1 ELISA试剂盒) metabolism and coagulation
This study is the first to associate enhancer RNAs with SERPINB2 and is the first demonstration of acquisition of NELF binding by enhancer RNAs on chromatin.
This study establishes a novel role for SerpinB2 in the stromal compartment in pancreatic ductal adenocarcinoma invasion through regulation of stromal remodelling
The variant of PAI-2 gene was associated with coronary artery disease and recurrent coronary event risk in Chinese Han population, in Xinjiang.
SerpinB2 plays an important role in proteostas
a total of 500 ESCC cases and 500 matched controls in a Southwest China population were evaluated for six SNPs in the exons of three Serpin genes (SerpinB5 (显示 SERPINB5 ELISA试剂盒), SerpinB2, and SerpinE1 (显示 SERPINE1 ELISA试剂盒)).
PAI-2 was up-regulated in tensioned keloid fibroblasts and normal fibroblasts, but more so in keloid cells. Knockdown of PAI2 reduced cell proliferation in fibroblasts under tension.
Soluble guanylate cyclase activators might alleviate or reverse vascular remodeling in pulmonary hypertension through the up-regulation of PAI-2.
We found no association between allele frequency and risk of multiples sclerosis for any single nucleotide polymorphism investigated for serpinb2
The efficient and rapid formation of uPA:PAI-2 complexes was thus shown to be associated with specific and rapid internalisation of PAI-2, which could be localised within endosomes and lysosomes
Data suggest that the function of keratinocyte SerpinB2 is protection of the stratum corneum from proteolysis via inhibition of urokinase, thereby maintaining the integrity and barrier function of the stratum corneum, particularly during times of skin inflammation
PAI-2 is a novel regulator of venous thrombus resolution, which modulates several pathways involving both inflammatory and uPA (显示 PLAU ELISA试剂盒) activity mechanisms, distinct from PAI-1 (显示 SERPINE1 ELISA试剂盒)
SerpinB2 has previously been implicated as a mediator of DMBA/TPA (显示 PLAT ELISA试剂盒)-induced skin carcinogenesis
The presence of SerpinB2 on the surface of MPs provides a physiological mechanism whereby cancer cell SerpinB2 can reach the extracellular milieu and access urokinase plasminogen (显示 PLG ELISA试剂盒) activator (uPA (显示 PLAU ELISA试剂盒)).
Brain metastatic cells from lung cancer and breast cancer express high levels of anti-plasminogen (显示 PLG ELISA试剂盒) activator (PA) serpins, including neuroserpin (显示 SERPINI1 ELISA试剂盒) and serpin B2, to prevent plasmin (显示 PLG ELISA试剂盒) generation and its metastasis-suppressive effects.
C/EBP-beta mediates both constitutive and LPS-induced serpinB2 mRNA expression in mouse embryonic fibroblasts and inflammatory primary macrophages.
Depletion PAI-2 resulted in NLRP3 (显示 NLRP3 ELISA试剂盒)- and ASC (显示 STS ELISA试剂盒)-dependent caspase-1 (显示 CASP1 ELISA试剂盒) activation and IL-1beta (显示 IL1B ELISA试剂盒) secretion in macrophages upon Toll-like receptor 2 (TLR2 (显示 TLR2 ELISA试剂盒)) and TLR4 (显示 TLR4 ELISA试剂盒) engagement.
SerpinB2 can be induced by lentiviral infection in vivo.
Inhibits urokinase-type plasminogen activator. The monocyte derived PAI-2 is distinct from the endothelial cell- derived PAI-1.
, placental plasminogen activator inhibitor
, plasminogen activator inhibitor 2
, plasminogen activator inhibitor, type II (arginine-serpin)
, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 2
, serpin B2
, urokinase inhibitor
, serine proteinase inhibitor, clade B, member 2
, plasminogen activator inhibitor type 2
, plasminogen activator inhibitor, type 2 (arginine-serpin)
, serpin peptidase inhibitor, clade B (ovalbumin), member 2
, plasminogen activator inhibitor 2, macrophage
, plasminogen activator inhibitor, type II
, serine (or cysteine) proteinase inhibitor, clade B, member 2
, plasminogen activator inhibitor 2 type A
, serine (or cysteine) peptidase inhibitor, clade B, member 2
, plasminogen activator inhibitor-2
, serine/cysteine proteinase inhibitor, clade B (ovalbumin), member 2