ATM 产品
(Ataxia Telangiectasia Mutated (ATM))
Categories
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates\; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].
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Featured ATM Categories
ATM 抗体
High quality antibodies with extensive validation data.
ATM ELISA试剂盒
Reliable ELISA kits for a wide range of species.
ATM 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATM 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA, FACS, FM
Validations
- (70)
- (12)
Cat. No.
ABIN6656104
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, FM
Validations
- (3)
- (5)
Cat. No.
ABIN6657494
Quantity
25 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC, ELISA, IF, IP, FACS, ICC
Validations
- (7)
Cat. No.
ABIN363380
Quantity
0.05 mL
Datasheet
Datasheet
Recommended ATM ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953956
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6953957
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Pig
Analytical Method
Quantitative Competition ELISA
Validations
Cat. No.
ABIN778066
Quantity
96 tests
Datasheet
Datasheet
Recommended ATM 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345994
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345996
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
Cat. No.
ABIN7393904
Quantity
100 μg
Datasheet
Datasheet
Latest Publications for our ATM Products
: "Localization of the kinase Ataxia Telangiectasia Mutated to Adenovirus E4 mutant DNA replication centers is important for its inhibitory effect on viral DNA accumulation." in: Virology, Vol. 527, pp. 47-56, (2019) (PubMed).: "N-Myc promotes therapeutic resistance development of neuroendocrine prostate cancer by differentially regulating miR-421/ATM pathway." in: Molecular cancer, Vol. 18, Issue 1, pp. 11, (2019) (PubMed).
: "Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks." in: Nature communications, Vol. 9, Issue 1, pp. 5342, (2019) (PubMed).
: "A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling." in: Aging cell, Vol. 18, Issue 1, pp. e12851, (2019) (PubMed).
: "ATM deficiency promotes progression of CRPC by enhancing Warburg effect." in: Endocrine-related cancer, Vol. 26, Issue 1, pp. 59-71, (2019) (PubMed).
: "The Augmented R-Loop Is a Unifying Mechanism for Myelodysplastic Syndromes Induced by High-Risk Splicing Factor Mutations." in: Molecular cell, Vol. 69, Issue 3, pp. 412-425.e6, (2019) (PubMed).
: "ATM phosphorylation of the actin-binding protein drebrin controls oxidation stress-resistance in mammalian neurons and C. elegans." in: Nature communications, Vol. 10, Issue 1, pp. 486, (2019) (PubMed).
: "PPARγ Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis." in: Cell reports, Vol. 26, Issue 5, pp. 1333-1343.e7, (2019) (PubMed).
: "Osteogenic differentiation of skeletal muscle progenitor cells is activated by the DNA damage response." in: Scientific reports, Vol. 9, Issue 1, pp. 5447, (2019) (PubMed).
: "PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo." in: The Journal of experimental medicine, Vol. 215, Issue 6, pp. 1749-1763, (2019) (PubMed).
Synonyms and alternative names related to ATM
telomere fusion (tefu), ATM serine/threonine kinase L homeolog (atm.L), ATM serine/threonine kinase (atm), ATM serine/threonine kinase (ATM), ataxia telangiectasia mutated (atm), ataxia telangiectasia mutated (EDI_100660), ataxia telangiectasia mutated (CpipJ_CPIJ001772), ataxia telangiectasia mutated (BDBG_08252), ataxia telangiectasia mutated (PAAG_02532), ataxia telangiectasia mutated (MCYG_05088), ataxia telangiectasia mutated (VDBG_06833), ataxia telangiectasia mutated (atm) (ACLA_015700), serine/threonine-protein kinase ATM (LOC5565620), ataxia telangiectasia mutated (MGYG_07634), ataxia telangiectasia mutated (PGTG_14279), ATM serine/threonine kinase (Atm), ataxia telangiectasia mutated (Atm), AI256621, at1, AT1, ATA, ATC, ATD, atdc, ATDC, ATE, ATM, Atm, atm, atm/tefu, C030026E19Rik, CG6535, dATM, Dmel\\CG6535, tef, Tefu, tel1, TEL1, telo1, TELO1, XatmProtein level used designations for ATM
- CG6535-PB
- ataxia telangiectasia mutated
- ataxia telengiesctasia mutated
- ataxia-telangiectasia mutated
- drosophila ATM
- tefu-PB
- chunp9624
- ataxia telangiectasia mutated (includes complementation groups A, C and D)
- ataxia telangiectasia mutated protein
- serine-protein kinase ATM-like
- ataxia telangiectasia mutated (atm)
- A-T mutated
- AT mutated
- TEL1, telomere maintenance 1, homolog
- serine-protein kinase ATM
- Ataxia telangiectasia gene mutated in human beings
- ataxia telangiectasia mutated homolog
- A-T mutated homolog
- ATM (ataxia telangiectasia mutated)
- ataxia telangiectasia gene mutated in human beings
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- ATP Synthase Subunit beta
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- ATP Synthase, H+ Transporting, Mitochondrial F0 Complex, Subunit E
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1A
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B
- ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4
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- ATP-Binding Protein p29
- ATP-Dependent Clp Protease Proteolytic Subunit 3
- ATP10
- ATP10A
- ATP10B
- ATP10D
- ATP11A
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