ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 产品
(ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B))
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008].
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Featured ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Categories
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 抗体
High quality antibodies with extensive validation data.
ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, FACS, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (4)
- (4)
Cat. No.
ABIN670161
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, FACS, IF (cc), IF (p), IHC (fro), IHC (p)
Validations
- (1)
Cat. No.
ABIN686977
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
ELISA, WB, IHC (fro), IHC (p)
Validations
Cat. No.
ABIN686979
Quantity
100 μL
Datasheet
Datasheet
Recommended ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3132561
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3132562
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3132560
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Products
: "The impact of insulin on chemotherapeutic sensitivity to 5-fluorouracil in gastric cancer cell lines SGC7901, MKN45 and MKN28." in: Journal of experimental & clinical cancer research : CR, Vol. 34, pp. 64, (2016) (PubMed).: "MicroRNA-186 induces sensitivity of ovarian cancer cells to paclitaxel and cisplatin by targeting ABCB1." in: Journal of ovarian research, Vol. 8, pp. 80, (2016) (PubMed).
: "Chronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis mice." in: Scientific reports, Vol. 5, pp. 13558, (2016) (PubMed).
: "Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells." in: PLoS ONE, Vol. 10, Issue 7, pp. e0131579, (2015) (PubMed).
: "Development of a novel orthotopic non-small cell lung cancer model and therapeutic benefit of 2'-(2-bromohexadecanoyl)-docetaxel conjugate nanoparticles." in: Nanomedicine : nanotechnology, biology, and medicine, Vol. 10, Issue 7, pp. 1497-506, (2014) (PubMed).
: "The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer." in: Journal of experimental & clinical cancer research : CR, Vol. 28, pp. 144, (2009) (PubMed).
Synonyms and alternative names related to ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B
ATP binding cassette subfamily B member 1 (ABCB1), ATP-binding cassette, sub-family B (MDR/TAP), member 1B (Abcb1b), ATP-binding cassette, subfamily B (MDR/TAP), member 1B (Abcb1b), ABC20, Abcb1, CD243, CLCS, GP170, mdr, MDR1, Mdr1, Mdr1b, P-GP, Pgy-1, PGY1, Pgy1Protein level used designations for ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B
- P-glycoprotein 1
- colchicin sensitivity
- doxorubicin resistance
- multidrug resistance protein 1
- ATP-binding cassette sub-family B member 1
- P glycoprotein 1
- multidrug resistance protein 1B
- ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
- ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
- ATP-binding cassette, sub-family B (MDR/TAP), member 1B
- ATP-binding cassette, subfamily B, member 1B
- P-glycoprotein/multidrug resistance 1
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