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The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.
T-lymphocyte maturation-associated protein
, myelin and lymphocyte protein
, myelin and lymphocyte protein, T-cell differentiation protein
, Myelin and lymphocyte protein
, 17 kDa myelin vesicular protein
, NS 3
, VIP17 proteolipid
, VIP17/MAL proteolipid
, MAL-like protein