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The major allele A of rs2511521 located in DRD2 (显示 DRD2 蛋白) and the minor allele T of rs625413 located in TIRAP (显示 TIRAP 蛋白) are significantly associated with increased risk of food addiction in overweight/obese subjects with low/zero food addiction symptoms.
Here the authors show that MAL TIR domains spontaneously and reversibly form filaments in vitro. They also form cofilaments with TLR4 (显示 TLR4 蛋白) TIR domains and induce formation of MyD88 (显示 MYD88 蛋白) assemblies.
Combined targeting of UBAP1 (显示 UBAP1 蛋白) and toll (显示 TLR4 蛋白)-like receptor adaptors TIRAP (显示 TIRAP 蛋白) and MyD88 (显示 MYD88 蛋白) by Pseudomonas aeruginosa PumA (显示 BBC3 蛋白) impedes both cytokine and toll (显示 TLR4 蛋白)-like receptor signalling, highlighting a novel strategy for innate immune evasion.
Epistatic interaction between MyD88 (显示 MYD88 蛋白) and TIRAP (显示 TIRAP 蛋白) against Helicobacter pylori.
Presence of at least one copy of the TIRAP (显示 TIRAP 蛋白) (2054C > T) variant may be associated with severity of bronchopulmonary dysplasia among preterm neonates.
MAL and TMEM220 were specifically methylated and were down-regulated in human gastric cancer.
Results show that MAl protein (显示 Mall 蛋白) binds to and regulates MYD88 (显示 MYD88 蛋白).
This study revealed that Merkel cell polyomavirus -negative Merkel cell carcinomas significantly expressed higher CADM1 and lower MAL than Merkel cell polyomavirus -positive Merkel cell carcinomas
CADM1/MAL methylation increases with severity of cervical intraepithelial neoplasia
TIRAP (显示 TIRAP 蛋白) polymorphisms are associated with progression and survival of patients with symptomatic myeloma.
Expression of the developmentally regulated proteolipid MAL is required for the cytotoxic effect of Clostridium perfringens Epsilon Toxin.
MAL (显示 TIRAP 蛋白) overexpression leads to reduced expression of Mpz and p75NTR (显示 NGFR 蛋白), despite functional pathways and normal expression of genes important for Schwann cell differentiation.
the exclusion of MAL from the expanding 2D crystals of uroplakins explains the selective association of MAL with the hinge areas in the uroplakin-delivering fusiform vesicles, as well as at the apical surface
Phagosomal retention of Francisella tularensis results in TIRAP/Mal (显示 TIRAP 蛋白)-independent TLR2 signaling.
The specific reduction and mistargeting of MAL protein (显示 Mall 蛋白) as a reaction to sulfatide overload may contribute to the pathogenic mechanisms in metachromatic leukodystrophy.
Our results demonstrate a critical role for MAL in the maintenance of central nervous system paranodes, likely by controlling the trafficking and/or sorting of NF155 and other membrane components in oligodendrocytes.
Our results suggest a functional role for MAL in peripheral myelination by influencing the expression of membrane components that mediate axon-glia interaction during ensheathment and myelin wrapping.
SYP is an hexameric MAL-domain channel protein.
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Down-regulation of this gene has been associated with a variety of human epithelial malignancies. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3.
T-lymphocyte maturation-associated protein
, myelin and lymphocyte protein
, myelin and lymphocyte protein, T-cell differentiation protein
, Myelin and lymphocyte protein
, 17 kDa myelin vesicular protein
, NS 3
, VIP17 proteolipid
, VIP17/MAL proteolipid
, MAL-like protein