ARHGEF3 产品
(rho Guanine Nucleotide Exchange Factor (GEF) 3 (ARHGEF3))
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Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured ARHGEF3 Categories
ARHGEF3 抗体
High quality antibodies with extensive validation data.
ARHGEF3 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended ARHGEF3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (2)
Cat. No.
ABIN7167981
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
ELISA
Validations
- (1)
- (1)
Cat. No.
ABIN565494
Quantity
50 μL
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, IHC
Validations
- (2)
Cat. No.
ABIN7264537
Quantity
200 μL
Datasheet
Datasheet
Recommended ARHGEF3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345551
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1345553
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3089362
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our ARHGEF3 Products
: "The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosis." in: Oncotarget, Vol. 7, Issue 18, pp. 25836-48, (2017) (PubMed).: "ARHGEF3 controls HDACi-induced differentiation via RhoA-dependent pathways in acute myeloid leukemias." in: Epigenetics : official journal of the DNA Methylation Society, Vol. 10, Issue 1, pp. 6-18, (2015) (PubMed).
: "Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells." in: Nature methods, Vol. 10, Issue 4, pp. 315-23, (2013) (PubMed).
Synonyms and alternative names related to ARHGEF3
Rho guanine nucleotide exchange factor (GEF) 3, gene 1 S homeolog (arhgef3.1.S), Rho guanine nucleotide exchange factor 3 (ARHGEF3), Rho guanine nucleotide exchange factor (GEF) 3 (arhgef3), Rho guanine nucleotide exchange factor (GEF) 3, gene 1 (arhgef3.1), Rho guanine nucleotide exchange factor (GEF) 3 (ARHGEF3), Rho guanine nucleotide exchange factor (GEF) 3 (Arhgef3), Rho guanine nucleotide exchange factor 3 (Arhgef3), 1200004I24Rik, 9830169H03Rik, ARHGEF3, C76747, DKFZp459N027, GEF3, MGC82822, MGC108040, si:ch211-258l4.8, STA3, XPLN, XplnProtein level used designations for ARHGEF3
- Rho guanine nucleotide exchange factor (GEF) 3
- Rho guanine nucleotide exchange factor 3
- rho guanine nucleotide exchange factor 3
- rho guanine nucleotide exchange factor 3-like
- 59.8 kDA protein
- RhoGEF protein
- exchange factor found in platelets and leukemic and neuronal tissues, XPLN
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