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CTCF 抗体

This anti-CTCF antibody is a 小鼠 单克隆 antibody detecting CTCF in WB 和 ELISA. Suitable for 人 和 猴. This Primary Antibody has been cited in 3+ publications.
产品编号 ABIN969071
发货至: 中国

Quick Overview for CTCF 抗体 (ABIN969071)

抗原

See all CTCF 抗体
CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

适用

  • 51
  • 34
  • 30
  • 8
  • 8
  • 7
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  • 5
  • 5
  • 4
  • 4
  • 2
  • 1
  • 1
人, 猴

宿主

  • 45
  • 5
  • 2
  • 1
  • 1
小鼠

克隆类型

  • 34
  • 20
单克隆

标记

  • 40
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
This CTCF antibody is un-conjugated

应用范围

  • 34
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  • 11
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  • 6
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  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA

克隆位点

1D11
  • 原理

    CTCF Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human CTCF expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Grbesa, Marinkovic, Ivkic, Kruslin, Novak-Kujundzic, Pegan, Bogdanovic, Bedekovic, Gall-Troselj: "Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma." in: Journal of molecular medicine (Berlin, Germany), Vol. 86, Issue 9, pp. 1057-66, (2008) (PubMed).

    Majumder, Gomez, Chadwick, Boss: "The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions." in: The Journal of experimental medicine, Vol. 205, Issue 4, pp. 785-98, (2008) (PubMed).

    Stedman, Kang, Lin, Kissil, Bartolomei, Lieberman: "Cohesins localize with CTCF at the KSHV latency control region and at cellular c-myc and H19/Igf2 insulators." in: The EMBO journal, Vol. 27, Issue 4, pp. 654-66, (2008) (PubMed).

  • 抗原

    CTCF (CCCTC-Binding Factor (Zinc Finger Protein) (CTCF))

    别名

    CTCF

    背景

    This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors.Tissue specificity: Ubiquitous. Absent in primary spermatocytes.

    分子量

    83 kDa

    UniProt

    P49711
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