GGA3 抗体 (AA 424-542)
(1 reference)-
- 抗原 See all GGA3 抗体
- GGA3 (Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3))
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抗原表位
- AA 424-542
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This GGA3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human GGA3 aa. 424-542
- 克隆位点
- 8-GGA3
- 亚型
- IgG1
- Top Product
- Discover our top product GGA3 Primary Antibody
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anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) (C-Term) antibody
GGA3 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) (AA 400-415) antibodyGGA3 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) (AA 342-503) antibodyGGA3 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) (C-Term) antibodyVerified GGA3 适用: 人 ELISA, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3) (AA 179-228) antibodyGGA3 适用: 人, 小鼠, 马, 犬, 斑马鱼, 豚鼠, Cow, Bat, Pig, 猴, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968537, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome." in: The Journal of cell biology, Vol. 149, Issue 1, pp. 67-80, (2000) (PubMed).
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: "A family of proteins with gamma-adaptin and VHS domains that facilitate trafficking between the trans-Golgi network and the vacuole/lysosome." in: The Journal of cell biology, Vol. 149, Issue 1, pp. 67-80, (2000) (PubMed).
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- 抗原
- GGA3 (Golgi-Associated, gamma Adaptin Ear Containing, ARF Binding Protein 3 (GGA3))
- 别名
- GGA3 (GGA3 产品)
- 别名
- C230037M19Rik antibody, mKIAA0154 antibody, golgi associated, gamma adaptin ear containing, ARF binding protein 3 antibody, Gga3 antibody, GGA3 antibody
- 背景
- The ADP-ribosylation factors (ARFs) are a family of small GTPases in the ARF superfamily that include ARFs and ARF-like (ARLs) proteins. At least six ARFs have been identified in humans: ARF1, ARF2, ARF3, ARF4, ARF5, and ARF6. ARFs are involved in intravesicular acidification and fusion of microsomal vesicles, endosome fusion, nuclear membrane assembly, and formation of clathrin-coated vesicles. GGAs are ARF-binding proteins that act as adaptor coat proteins associated with the Golgi complex. GGA1, GGA2, and GGA3 are homologous proteins that contain N-terminal VHS domains, a GGA and TOM homology region (GAT), and a C-terminal region homologous to the ear domain of gamma-adaptins. GGAs co-localize with Golgi markers in the TGN, and GGA3 is found present in coated vesicles and buds associated with the TGN. The GAT domain of GGA3 facilitates ARF1 binding, Golgi localization, and dissociation from ARF-regulated membranes. The C-terminal region of GGAs bind to MAP1A and rabaptin-5, which are binding partners of gamma-adaptins. Overexpression of GGAs alters the distribution of markers normally found in the TGN. Thus, GGAs are ARF binding proteins that regulate vesicle dynamics in the TGN.
- 分子量
- 90 kDa
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