我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

XPO1 抗体 (AA 2-122)

Name: XPO1 抗体 (AA 2-122)
SKU: ABIN968674
Availability: OutOfStock

This anti-XPO1 antibody is a 小鼠单克隆 antibody detecting XPO1 in WB 和 IF. Suitable for 人, 小鼠, 大鼠, 犬和小鸡. This Primary Antibody has been cited in 6+ publications.

Western blot analysis of Exportin-1 on WI-38 lysate. (XPO1 抗体 (AA 2-122))

Immunofluorescent staining on SK-BR3 cells. (XPO1 抗体 (AA 2-122))

2 images

(6 references)

产品编号 ABIN968674

发货至: 中国

Datasheet as PDF

Quick Overview for XPO1 抗体 (AA 2-122) (ABIN968674)

抗原

See all XPO1 抗体

XPO1 (Exportin 1 (XPO1))

适用

人, 小鼠, 大鼠, 犬, 小鸡

宿主

小鼠

克隆类型

单克隆

标记

This XPO1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

17-Exportin

Discover our top product XPO1 Primary Antibody

抗原表位
15

11

7

5

5

4

3

2

2

2

1

1

1

1
AA 2-122

交叉反应

小鸡, 犬, 小鼠, 大鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human hCRM1 aa. 2-122

亚型

IgG1
anti-Exportin 1 (XPO1) (AA 966-1071) antibody
XPO1 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) (AA 625-845) antibody
XPO1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) (C-Term) antibody
XPO1 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 斑马鱼, 兔, Pig, Saccharomyces cerevisiae WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) (AA 917-1071) antibody
XPO1 适用: 人 WB, IHC, FACS 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) antibody
XPO1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) (AA 701-800) antibody
XPO1 适用: 人, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) (acLys568) antibody
XPO1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) antibody
XPO1 适用: 人 ELISA, IHC 宿主: 兔 Monoclonal 9F2 unconjugated Recombinant Antibody

anti-Exportin 1 (XPO1) (acLys568) antibody
XPO1 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Exportin 1 (XPO1) (AA 966-1071) antibody
XPO1 适用: 人, 小鼠, 大鼠 WB, IHC, FACS, IF, ICC 宿主: 小鼠 Monoclonal 5G3 unconjugated

说明

Related Products: ABIN968553, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Kamura, Hara, Matsumoto, Ishida, Okumura, Hatakeyama, Yoshida, Nakayama, Nakayama: "Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase." in: Nature cell biology, Vol. 6, Issue 12, pp. 1229-35, (2004) (PubMed).

Ishida, Hara, Kamura, Yoshida, Nakayama, Nakayama: "Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 14355-8, (2002) (PubMed).

Massenet, Pellizzoni, Paushkin, Mattaj, Dreyfuss: "The SMN complex is associated with snRNPs throughout their cytoplasmic assembly pathway." in: Molecular and cellular biology, Vol. 22, Issue 18, pp. 6533-41, (2002) (PubMed).

Paraskeva, Izaurralde, Bischoff, Huber, Kutay, Hartmann, Lührmann, Görlich: "CRM1-mediated recycling of snurportin 1 to the cytoplasm." in: The Journal of cell biology, Vol. 145, Issue 2, pp. 255-64, (1999) (PubMed).

Boer, Bonten-Surtel, Grosveld: "Overexpression of the nucleoporin CAN/NUP214 induces growth arrest, nucleocytoplasmic transport defects, and apoptosis." in: Molecular and cellular biology, Vol. 18, Issue 3, pp. 1236-47, (1998) (PubMed).

Fornerod, Ohno, Yoshida, Mattaj: "CRM1 is an export receptor for leucine-rich nuclear export signals." in: Cell, Vol. 90, Issue 6, pp. 1051-60, (1997) (PubMed).
抗原

XPO1 (Exportin 1 (XPO1))

别名

Exportin-1

背景

The nuclear pore complex (NPC) is a 125 MDa nuclear envelope complex that mediates nucleocytoplasmic shuttling of RNA and protein. NPC is comprised of more than 30 different proteins, including Ran/TC4, importins, and exportins . Exportin-1(hCRM1/XPO1) is the widely expressed human homologue of the yeast CRM1 protein, which functions in the maintenance of chromatin structure and nuclear export. Exportin-1 has an N-terminal CRIME domain that is homologous to yeast CRM1 and importin-beta. Intracellular localization of Exportin-1 shows association with the NPC and overexpression of Exportin-1 in Xenopus oocytes stimulates Rev and U snRNA export from the nucleus. Exportin-1 also binds other nuclear transport related proteins, such as RanGTP, snurportin-1, and the nucleoporins CAN/Nup214 and Nup50. Overexpression of CAN leads to sequestration of Exportin-1 in the nucleoplasm, which inhibits cell growth and induces apoptosis. In addition, Exportin-1 may export specific proteins, such as Rev and PKI, via binding to a leucine-rich nuclear export signal (NES). Thus, Exportin-1 is an important protein and RNA nuclear export receptor, which may be required for normal cell growth and survival. This antibody is routinely tested by western blot analysis.
Synonyms: CRM1

分子量

112 kDa

途径

M Phase