CNKSR1 抗体 (AA 10-217)
(2 references)-
- 抗原 See all CNKSR1 抗体
- CNKSR1 (Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1))
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抗原表位
- AA 10-217
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CNKSR1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF)
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human hCNK1 aa. 10-217
- 克隆位点
- 46-hCNK1
- 亚型
- IgG1
- Top Product
- Discover our top product CNKSR1 Primary Antibody
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anti-Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) (AA 111-210) antibody
CNKSR1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) (Internal Region) antibodyCNKSR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) (Internal Region) antibodyCNKSR1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) (Internal Region) antibodyCNKSR1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) (AA 1-720) antibodyCNKSR1 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1) (AA 545-594) antibodyCNKSR1 适用: 人, 马, 兔, 猴 WB 宿主: 兔 Polyclonal unconjugated
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- 说明
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Related Products: ABIN968533, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Functional analysis of CNK in RAS signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13259-63, (1999) (PubMed).
: "CNK, a RAF-binding multidomain protein required for RAS signaling." in: Cell, Vol. 95, Issue 3, pp. 343-53, (1998) (PubMed).
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: "Functional analysis of CNK in RAS signaling." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13259-63, (1999) (PubMed).
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- 抗原
- CNKSR1 (Connector Enhancer of Kinase Suppressor of Ras 1 (CNKSR1))
- 别名
- hCNK1 (CNKSR1 产品)
- 别名
- zgc:77200 antibody, CNKSR1 antibody, cnk antibody, ksr antibody, cnk1 antibody, CNK antibody, CNK1 antibody, KSR antibody, BC037758 antibody, connector enhancer of kinase suppressor of Ras 1 antibody, connector enhancer of kinase suppressor of Ras 1 L homeolog antibody, cnksr1 antibody, CNKSR1 antibody, cnksr1.L antibody, Cnksr1 antibody
- 背景
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Proteins of the Ras superfamily play critical roles in the control of normal and neoplastic proliferation. These proteins relay signals from Tyr-kinases at the plasma membrane to the nucleus via a network of Ser/Thr kinases that includes the MAP kinase (Raf-MEK-ERK) pathway. Kinase suppressor of Ras (KSR-1) was discovered in Drosophila in a genetic screen that identified mutations that suppress constitutively active Ras mutants. Connector enhancer of KSR (CNK) was found in a similar screen to identify mutations that enhance the KSR- dependent phenotype. Drosophila CNK contains a sterile alpha motif (SAM), a conserved region in CNK (CRIC), and a PDZ domain in the N-terminal region, a proline-rich and a plecstrin homology (PH) domain in the central region, and a C-terminal Pro-rich domain. The human homologue of CNK (hCNK1) contains similar N-terminal and central domains, but is 713 amino acids in length compared to 1557 amino acids for Drosophila CNK. In Drosophila, the N-terminal region of CNK facilitates binding to RAS, while the C-terminal region inhibits RAS- and RAF-dependent signaling. Thus, CNK may be important for regulation of both RAS- and RAF-dependent signaling.
Synonyms: Connector enhancer of KSR - 分子量
- 79-100 kDa
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