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CD51 抗体 (AA 609-722)

Name: CD51 抗体 (AA 609-722)
SKU: ABIN968314
Availability: OutOfStock

This anti-CD51 antibody is a 小鼠单克隆 antibody detecting CD51 in WB 和 IF. Suitable for 人, 小鼠, 大鼠和犬. This Primary Antibody has been cited in 3+ publications.

Western blot analysis of CD51 (Integrin alphaV) on a rat cerebrum lysate. (CD51 抗体 (AA 609-722))

Immunofluorescence staining of human endothelial cells. (CD51 抗体 (AA 609-722))

2 images

(3 references)

产品编号 ABIN968314

发货至: 中国

Datasheet as PDF

Quick Overview for CD51 抗体 (AA 609-722) (ABIN968314)

抗原

See all CD51 (ITGAV) 抗体

CD51 (ITGAV) (Integrin alpha V (ITGAV))

适用

人, 小鼠, 大鼠, 犬

宿主

小鼠

克隆类型

单克隆

标记

This CD51 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

21-CD51

Discover our top product ITGAV Primary Antibody

抗原表位
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1

1
AA 609-722

交叉反应

大鼠, 犬, 小鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human CD51/VNRalpha aa. 609-722

亚型

IgG1 kappa
anti-Integrin alpha V (ITGAV) antibody
ITGAV 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated

anti-Integrin alpha V (ITGAV) (C-Term) antibody
ITGAV 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) (AA 560-744) antibody
ITGAV 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) (AA 775-885) antibody
ITGAV 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) (AA 51-150) antibody
ITGAV 适用: 人, 小鼠 WB, FACS, ELISA, IHC (fro), IF (p), IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) (AA 71-322) antibody
ITGAV 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) antibody
ITGAV 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) (AA 1-1048) antibody
ITGAV 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) (AA 1-1048) antibody
ITGAV 适用: 人 WB, PLA 宿主: 小鼠 Polyclonal unconjugated

anti-Integrin alpha V (ITGAV) (C-Term) antibody
ITGAV 适用: 人, 小鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968545, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Bodary, McLean: "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line." in: The Journal of biological chemistry, Vol. 265, Issue 11, pp. 5938-41, (1990) (PubMed).

Suzuki, Argraves, Arai, Languino, Pierschbacher, Ruoslahti: "Amino acid sequence of the vitronectin receptor alpha subunit and comparative expression of adhesion receptor mRNAs." in: The Journal of biological chemistry, Vol. 262, Issue 29, pp. 14080-5, (1987) (PubMed).

Suzuki, Argraves, Pytela, Arai, Krusius, Pierschbacher, Ruoslahti: "cDNA and amino acid sequences of the cell adhesion protein receptor recognizing vitronectin reveal a transmembrane domain and homologies with other adhesion protein receptors." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 22, pp. 8614-8, (1986) (PubMed).
抗原

CD51 (ITGAV) (Integrin alpha V (ITGAV))

别名

CD51

背景

Integrins are a family of proteins that mediate intercellular adhesion or adherence to extracellular matrix proteins. Their roles are essential for embryonic development, tumor metastasis, organ function, and proper immune cell function. Family members are heterodimers that contain a larger alpha subunit that is unique to each individual receptor and a smaller beta subunit that can be shared by several receptors. Based on beta subunit content, integrins are divided into the subfamilies beta1, beta2, and beta3. The beta3 subfamily contains the vitronectin receptor (alphaVbeta3) and the platelet protein gpIIb/IIIa. The alpha chain of the vitronectin receptor (VNRalpha, CD51, integrin alphaV) has been reported to consist of a disulfide-linked large extracellular (125 kDa) subunit and a smaller (25 kDa) membrane-anchored subunit. The large subunit contains multiple sequences with homology to calcium-binding sites in other proteins and an RGD-dependent ligand-binding site, while the small subunit contains a transmembrane domain and a short cytoplasmic domain. VNRalpha has been reported to be noncovalently associated with the VNR beta3-chain (CD61, gpIIIa). The VNR mediates cell adhesion to RGD-containing ligands such as vitronectin, von Willebrand factor, fibrinogen, and thrombospondin. This antibody is routinely tested by western blot analysis.
Synonyms: Integrin alphaV, Vitronectin Receptor alpha, VNRalpha

分子量

125 kDa

途径

Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Integrin Complex