RABEP1 抗体 (AA 247-417)
(3 references)-
- 抗原 See all RABEP1 抗体
- RABEP1 (Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1))
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抗原表位
- AA 247-417
- 适用
- 人, 小鼠, 大鼠
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This RABEP1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)
- 交叉反应
- 小鼠, 大鼠
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human Rabaptin-5 aa. 247-417.
- 克隆位点
- 20-Rabaptin
- 亚型
- IgG1
- Top Product
- Discover our top product RABEP1 Primary Antibody
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anti-Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1) (AA 765-862) antibody
RABEP1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 3H6 unconjugated
anti-Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1) (AA 1-255) antibodyRABEP1 适用: 人 ELISA, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1) (AA 427-461) antibodyRABEP1 适用: 小鼠 WB 宿主: 兔 Polyclonal RB52806 unconjugated
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- 说明
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Related Products: ABIN968585, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 250 μg/mL
- 缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store undiluted at -20° C.
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: "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain." in: Journal of biochemistry, Vol. 131, Issue 3, pp. 327-36, (2002) (PubMed).
: "Binding of GGA2 to the lysosomal enzyme sorting motif of the mannose 6-phosphate receptor." in: Science (New York, N.Y.), Vol. 292, Issue 5522, pp. 1716-8, (2001) (PubMed).
: "Rabaptin-5 is a direct effector of the small GTPase Rab5 in endocytic membrane fusion." in: Cell, Vol. 83, Issue 3, pp. 423-32, (1996) (PubMed).
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: "Gamma-adaptin interacts directly with Rabaptin-5 through its ear domain." in: Journal of biochemistry, Vol. 131, Issue 3, pp. 327-36, (2002) (PubMed).
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- 抗原
- RABEP1 (Rabaptin, RAB GTPase Binding Effector Protein 1 (RABEP1))
- 别名
- Rabaptin-5 (RABEP1 产品)
- 别名
- RAB5EP antibody, RABPT5 antibody, AA409789 antibody, AI481320 antibody, AV213537 antibody, AW240603 antibody, Rab5ep antibody, rabaptin-5 antibody, rabaptin, RAB GTPase binding effector protein 1 antibody, RABEP1 antibody, Rabep1 antibody
- 背景
- Rabs are small GTP-binding proteins that are localized to specific intracellular vesicles and organelles. They are important for the regulation of vesicular traffic. It is thought that Rabs cycle between GTP- and GDP-bound forms and this cycle is related to their function. Rabaptin-5 is protein that interacts with GTP-Rab5. Although Rabaptin-5 is localized in the cytosol, it is also recruited to the endosomal fraction in a Rab5 and GTP-dependent manner. The removal of Rabaptin-5 from the cytosol substantially impairs GTP and Rab5-dependent endosomal fusion. This indicates that Rabaptin-5 may be an important partner of Rab5 during endocytosis. Rabaptin-5 contains 862 amino acids and both ends of the protein contain coiled-coil domains typically found in vesicular transport proteins. This antibody is routinely tested by western blot analysis.
- 分子量
- 117 kDa
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