TDG 抗体 (C-Term)
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Quick Overview for TDG 抗体 (C-Term) (ABIN967162)
抗原
See all TDG 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human TDG (G/T mismatch-specific thymine DNA glycosylase)
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anti-Thymine-DNA Glycosylase (TDG) (AA 141-410) antibody
TDG 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (Internal Region) antibodyTDG 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 1-410) antibodyTDG 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 1-160) antibodyTDG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 1-410) antibodyTDG 适用: 人 WB, ELISA, IF, ICC 宿主: 小鼠 Monoclonal AT2F7 unconjugated
anti-Thymine-DNA Glycosylase (TDG) antibodyTDG 适用: 人, 小鼠, 大鼠 IF 宿主: 兔 Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 1-410) antibodyTDG 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) antibodyTDG 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 281-310), (C-Term) antibodyTDG 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB19894 unconjugated
anti-Thymine-DNA Glycosylase (TDG) (AA 81-110), (N-Term) antibodyTDG 适用: 人, 小鼠 WB, FACS 宿主: 兔 Polyclonal RB19893 unconjugated
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限制
- 仅限研究用
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储存条件
- 4 °C
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: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).
: "Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover." in: The EMBO journal, Vol. 21, Issue 6, pp. 1456-64, (2002) (PubMed).
: "Cloning and expression of human G/T mismatch-specific thymine-DNA glycosylase." in: The Journal of biological chemistry, Vol. 271, Issue 22, pp. 12767-74, (1996) (PubMed).
: "Efficient removal of uracil from G.U mispairs by the mismatch-specific thymine DNA glycosylase from HeLa cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 5, pp. 1642-6, (1994) (PubMed).
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: "Crystal structure of thymine DNA glycosylase conjugated to SUMO-1." in: Nature, Vol. 435, Issue 7044, pp. 979-82, (2005) (PubMed).
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- TDG (Thymine-DNA Glycosylase (TDG))
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别名
- TDG
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背景
- In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. TDG(G/T mismatch-specific thymine DNA glycosylase) corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, TDG can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. TDG can also remove uracil and 5-bromouracil from mispairs with guanine. Sumoylation on Lys-330 by either SUMO1 or SUMO2 induces dissociation of the product DNA. TDG belongs to the TDG/mug DNA glycosylase family.
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途径
- DNA Damage Repair, Chromatin Binding
抗原
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