我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

ATM 抗体 (pSer1981)

Name: ATM 抗体 (pSer1981)
SKU: ABIN964571
Availability: OutOfStock

ATM 适用: 人 WB, ELISA 宿主: 绵羊 Polyclonal unconjugated

Western Blot of Sheep Anti-ATM pS1981 polyclonal antibody. (ATM 抗体 (pSer1981))

Schematic of ATM induction by DNA damage. (ATM 抗体 (pSer1981))

2 images

产品编号 ABIN964571

Supplier Product No.: 600-601-400

发货至: 中国

Datasheet as PDF

抗原 See all ATM 抗体

ATM (Ataxia Telangiectasia Mutated (ATM))
抗原表位
30

16

15

13

8

7

7

7

7

5

4

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
pSer1981
适用
153

66

31

1

1

1
人
宿主
125

23

5

1
绵羊
克隆类型
120

34
多克隆
标记
78

8

7

5

4

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

3

2

2
This ATM antibody is un-conjugated
应用范围
68

50

39

35

28

24

24

21

20

12

8

7

4

3

2

2

1
Western Blotting (WB), ELISA

Supplier Product No.

600-601-400

Supplier

Rockland

原理

ATM phospho S1981 Antibody

交叉反应（详细）

This affinity-purified antibody is directed against human ATM and is useful in determining its presence in various assays. This polyclonal anti-ATM antibody recognizes the phosphorylated epitope in native and over-expressed proteins found in various tissues and extracts.

产品特性

Synonyms: sheep anti-ATM pS1981 Antibody, AT mutated antibody, AT protein antibody, AT1 antibody, ATA antibody, Ataxia telangiectasia gene mutated in human beings antibody, Ataxia telangiectasia mutated antibody, ATC antibody

纯化方法

Affinity purified antibody

过滤

Sterile filtered

免疫原

Immunogen: This antibody was affinity purified from whole sheep serum prepared by repeated immunizations with a synthetic peptide corresponding to a region near serine 1981 of human ATM conjugated to KLH using maleimide.
Immunogen Type: Conjugated Peptide

亚型

IgG

Top Product

Discover our top product ATM Primary Antibody
anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人 WB, IHC, ELISA, IP, IF, FACS, FM 宿主: 小鼠 Monoclonal 10H11-E12 unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人 WB, IHC, ELISA, IP, IF, FACS, FM 宿主: 小鼠 Monoclonal 10H11-E12 unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (C-Term) antibody
ATM 适用: 人, 小鼠 WB, IHC, ELISA, IP, IF, FACS, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 2681-2750) antibody
ATM 适用: 人, 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 2484-2748) antibody
ATM 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) antibody
ATM 适用: 人 WB, IHC, ELISA, IP 宿主: 兔 Monoclonal 4E11 unconjugated Recombinant Antibody

anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody
ATM 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 7C10D8 unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) (AA 1974-1988), (pSer1981) antibody (HRP)
ATM 适用: 人 WB, IHC, ELISA, FM 宿主: 小鼠 Monoclonal 10H11-E12 HRP

anti-Ataxia Telangiectasia Mutated (ATM) (AA 486-742) antibody
ATM 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Ataxia Telangiectasia Mutated (ATM) antibody
ATM 适用: 人 IHC, ELISA, FACS 宿主: 兔 Monoclonal 3G11 unconjugated Recombinant Antibody

应用备注

Application Note: Affinity purified sheep anti-ATM has been tested by ELISA and western blotting against native form phosphorylated ATM PK.
Western Blot Dilution: 1:500 - 1:2,000
ELISA Dilution: 1:2,000 - 1:10,000
Other: User Optimized

限制

仅限研究用
状态

Liquid

浓度

1.0 mg/mL

缓冲液

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

有效期

12 months
抗原

ATM (Ataxia Telangiectasia Mutated (ATM))

别名

ATM (ATM 产品)

背景

Background: ATM, the gene mutated in the hereditary disease ataxia-telangiectasia, codes for a protein kinase that acts as a master regulator of cellular responses to DNA double-strand breaks. ATM is normally inactive and the question of how it is activated in the event of DNA damage (due to ionizing radiation for instance) is central to understanding its function. ATM protein is now shown to be present in undamaged cells as an inactive dimer. Low doses of ionizing radiation, which induce only a few DNA breaks, activate at least half of the total ATM protein present, possibly in response to changes in chromatin structure. The ATM gene encodes a 370- kDa protein that belongs to the phosphoinositide 3-kinase (PI(3)K) superfamily, but which phosphorylates proteins rather than lipids. The 350-amino-acid kinase domain at the carboxy terminus of this large protein is the only segment of ATM with an assigned function. Exposure of cells to IR triggers ATM kinase activity and this function is required for arrests in G1, S and G2 phases of the cell cycle. Several substrates of the ATM kinase participate in these IR-induced cell-cycle arrests. These include p53, Mdm2 and Chk2 in the G1 checkpoint, Nbs1, Brca1, FancD2 and SMC1 in the transient IR-induced S-phase arrest, and Brca1 and hRad17 in the G2/M checkpoint. This antibody is similar to the rabbit host antibody discussed by Bakkenist, C. J. & Kastan, M. B. in Nature 421, 499-506 (2003).

基因ID

472

NCBI登录号

NP_000042

UniProt

Q13315

途径

p53 Pathway, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus