GSAP 抗体 (C-Term)
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Quick Overview for GSAP 抗体 (C-Term) (ABIN954149)
抗原
See all GSAP (PION) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 536-565, C-Term
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特异性
- This antibody recognizes Human PION (C-term).
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纯化方法
- Affinity Chromatography on Protein A
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免疫原
- KLH conjugated synthetic peptide between 536-565 amino acids from the C-terminal region of human PION
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亚型
- Ig Fraction
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anti-Pigeon Homolog (PION) (AA 616-854) antibody
PION 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (N-Term) antibodyPION 适用: 人, 大鼠, Cow, 犬, 马, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (C-Term) antibodyPION 适用: 人, 大鼠, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- GSAP (PION) (Pigeon Homolog (PION))
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别名
- PION / GSAP
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背景
- Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD, MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1, MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP, MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog
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分子量
- 97802 Da
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基因ID
- 54103
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NCBI登录号
- NP_059135
抗原
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