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- 抗原 See all GSAP (PION) 抗体
- GSAP (PION) (Pigeon Homolog (PION))
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抗原表位
- C-Term
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适用
- 人, 大鼠, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GSAP antibody is un-conjugated
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应用范围
- Western Blotting (WB), Enzyme Immunoassay (EIA)
- 特异性
- This antibody detects PION at C-term. Multiple isoforms of PION are known to exist. PION antibody is predicted to not cross-react with other F-box protein family members.
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse, rat
- 纯化方法
- Affinity chromatography purified via peptide column
- 免疫原
- 19 amino acid peptide near the carboxy terminus of human PION
- Top Product
- Discover our top product PION Primary Antibody
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anti-Pigeon Homolog (PION) (AA 616-854) antibody
PION 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (AA 536-565), (C-Term) antibodyPION 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Pigeon Homolog (PION) (N-Term) antibodyPION 适用: 人, 大鼠, 马, 兔, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
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- 缓冲液
- PBS containing 0.02 % sodium azide
- 储存液
- Sodium azide
- 注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- 4 °C/-20 °C
- 储存方法
- Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.
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- 抗原
- GSAP (PION) (Pigeon Homolog (PION))
- 别名
- PION / GSAP (PION 产品)
- 别名
- PION antibody, A530088I07Rik antibody, Pion antibody, gamma-secretase activating protein antibody, GSAP antibody, Gsap antibody
- 背景
- Accumulation of the amyloid-β peptide (Aβ) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer s disease. The β-amyloid protein precursor (APP) is cleaved by one of two β-secretases (BACE and BACE2), producing a soluble derivative of the protein and a membrane anchored 99 -amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for γ?secretase to generate the 4 kDa amyloid-β peptide (Aβ), which is deposited in the Alzheimer's disease patients' brains. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and the APP C-terminal fragment, suggesting that PION may be a potential therapeutic target for the treatment of Alzheimer's disease.Synonyms: Gamma-secretase-activating protein, Protein pigeon homolog
- 基因ID
- 54103
- NCBI登录号
- NP_059135
- UniProt
- A4D1B5
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