NDUFS2 is a core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Mammalian mitochondrial complex I is composed of at least 43 different subunits, 7 of which are encoded by the mitochondrial genome, and the rest are the products of nuclear genes. The iron-sulfur protein fraction of complex I is made up of 7 subunits, including this gene product. Complex I catalyzes the NADH oxidation with concomitant ubiquinone reduction and proton ejection out of the mitochondria.Synonyms: CI-49kD, Complex I-49kD, NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, NADH-ubiquinone oxidoreductase 49 kDa subunit, mitochondrial